Current Issue April 2012, Vol. 27, No. 2

Issue Highlights

Implementation challenges in the intensive care unit: The why, who, and how of daily interruption of sedation
Despite strong medical evidence and policy initiatives supporting the use of daily interruption of sedation in mechanically ventilated patients, compliance remains suboptimal. We sought to identify new barriers to daily interruption of sedation.
Effects of intracellular acidosis on endothelial function: An overview
This review presents a current perspective of the effects of intracellular acidosis on the function and the basic regulatory mechanisms of endothelial cells.
Blood glucose amplitude variability as predictor for mortality in surgical and medical intensive care unit patients: a multicenter cohort study
The aim of this study was to test the hypothesis that blood glucose amplitude variability (BGAV) is associated with mortality in critically ill patients.

African American race, obesity, and blood product transfusion are risk factors for acute kidney injury in critically ill trauma patients
17 May 2012
Michael G.S. Shashaty, Nuala J. Meyer, A. Russell Localio, Robert Gallop, Scarlett L. Bellamy, Daniel N. Holena, Paul N. Lanken, Sandra Kaplan, Dilek Yarar, Steven M. Kawut, Harold I. Feldman, Jason D. Christie
Abstract: Purpose: Acute kidney injury (AKI) is a common source of morbidity after trauma. We sought to determine novel risk factors for AKI, by Acute Kidney Injury Network (AKIN) criteria, in critica...
Discordance between microcirculatory alterations and arterial pressure in patients with hemodynamic instability
17 May 2012
Ryan C. Arnold, R. Phillip Dellinger, Joseph E. Parrillo, Michael E. Chansky, Vincent E. Lotano, Jonathan V. McCoy, Alan E. Jones, Nathan I. Shapiro, Steven M. Hollenberg, Stephen Trzeciak
Abstract: Purpose: Recent studies reported that microcirculatory blood flow alterations occur in patients with circulatory shock independent of arterial pressure but typically lack baseline microcircu...
Influence of full-time intensivist and the nurse-to-patient ratio on the implementation of severe sepsis bundles in Korean intensive care units
17 May 2012
Je Hyeong Kim, Suk-Kyung Hong, Kyung Chan Kim, Myung-Goo Lee, Ki Man Lee, Sung Soo Jung, Hye Sook Choi, Jin Hwa Lee, Ki-Suk Jung, Sung-Soon Lee, Jae Hwa Cho, Shin Ok Koh, Moo Suk Park, Kwang Won Seo, Younsuck Koh
Abstract: Purpose: The reported actual compliance for severe sepsis bundles was very low, suggesting the presence of barriers to their implementation. The purpose of this study was to assess the influ...
Chronic heart failure modifies the response to positive end-expiratory pressure in patients with chronic obstructive pulmonary disease
17 May 2012
Shailesh Bihari, Andrew D. Bersten
Abstract: Introduction: Potentially beneficial effects of positive end-expiratory pressure (PEEP) in patients with chronic obstructive pulmonary disease (COPD) must be balanced against further overinf...
Extracorporeal membrane oxygenation–assisted primary percutaneous coronary intervention may improve survival of patients with acute myocardial infarction complicated by profound cardiogenic shock
17 May 2012
Nai-Wen Tsao, Chun-Ming Shih, Jong-Shiuan Yeh, Yung-Ta Kao, Ming-Hsiung Hsieh, Keng-Liang Ou, Jaw-Wen Chen, Kou-Gi Shyu, Zen-Chung Weng, Nen-Chung Chang, Feng-Yen Lin, Chun-Yao Huang
Abstract: Purpose: The aim of this study was to evaluate the impact of extracorporeal membrane oxygenation (ECMO) assistance on the clinical outcome of patients with acute myocardial infarction (AMI) ...

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Vasopressor administration and sepsis: A survey of Canadian intensivists
October 2011 (Vol. 26 | No. 5 | Pages 532.e1-532.e7)
Francois Lamontagne, Deborah J. Cook, Neill K.J. Adhikari, Matthias Briel, Mark Duffett, Michelle E. Kho, Karen E.A. Burns, Gordon Guyatt, Alexis F. Turgeon, Qi Zhou, Maureen O. Meade
A European care bundle for management of ventilator-associated pneumonia
February 2011 (Vol. 26 | No. 1 | Pages 3-10)
Jordi Rello, Jean Chastre, Giuseppe Cornaglia, Robert Masterton
PROphylaxis for ThromboEmbolism in Critical Care Trial protocol and analysis plan
April 2011 (Vol. 26 | No. 2 | Pages 223.e1-223.e9)
Deborah Cook, Maureen Meade, Gordon Guyatt, Stephen D. Walter, Diane Heels-Ansdell, William Geerts, Theodore E. Warkentin, D. Jamie Cooper, Nicole Zytaruk, Shirley Vallance, Otavio Berwanger, Marcelo Rocha, Ismael Qushmaq, Mark Crowther
Postobstructive pulmonary edema
September 2010 (Vol. 25 | No. 3 | Pages 538.e1-538.e5)
Ashish Udeshi, Shawn Michael Cantie, Edgar Pierre
Reduced mortality after the implementation of a protocol for the early detection of severe sepsis
February 2011 (Vol. 26 | No. 1 | Pages 76-81)
Glauco A. Westphal, Álvaro Koenig, Milton Caldeira Filho, Janaína Feijó, Louise Trindade de Oliveira, Fernanda Nunes, Kênia Fujiwara, Sheila Fonseca Martins, Anderson R. Roman Gonçalves

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The Journal of Critical Care, the official journal of the World Federation of Societies of Intensive and Critical Care Medicine (WFSICCM) and Society for Complexity in Acute Illness (SCAI), provides a forum for the publication of original peer-reviewed articles with the goal of improving patient care by integrating critical care systems knowledge into practice behavior. Topics will include biomedical research, epidemiology, biostatistics, health policy research, social sciences, technology development, and relevant legal and ethical concerns. The Journal will also invite articles discussing current, state of the art, and sometimes controversial topics in anesthesiology, perioperative and critical care medicine. The editorial board represents an international cross section of individuals actively involved in the disciplines of Critical Care Medicine and Anesthesiology.

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Implementation challenges in the intensive care unit: The why, who, and how of daily interruption of sedation
Melissa A. Miller, Emily A. Bosk, Theodore J. Iwashyna, Sarah L. Krein

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