Journal of Critical Care
Volume 21, Issue 3 , Pages 259-265 , September 2006

C-reactive protein concentration as a predictor of intensive care unit readmission: A nested case-control study

  • Kwok M. Ho, MBBS, MPH, MRCP, FANZCA, FJFICM

      Affiliations

    • Department of Intensive Care, Royal Perth Hospital, Perth, WA 6000, Australia
    • School of Medicine and Pharmacology, University of Western Australia, Perth, WA 6000, Australia
    • Corresponding Author InformationCorresponding author. ICU, Royal Perth Hospital, Wellington Street, Perth, WA 6000.
  • ,
  • Geoffrey J. Dobb, BSc, MBBS, MRCP, FRCA, FANZCA, FJFICM

      Affiliations

    • Department of Intensive Care, Royal Perth Hospital, Perth, WA 6000, Australia
    • School of Medicine and Pharmacology, University of Western Australia, Perth, WA 6000, Australia
  • ,
  • Kok Y. Lee, MBBS, B Med Sc, FRACP

      Affiliations

    • Department of Intensive Care, Royal Perth Hospital, Perth, WA 6000, Australia
  • ,
  • Simon C. Towler, MBBS, FAMA, FANZCA, FJFICM

      Affiliations

    • Department of Intensive Care, Royal Perth Hospital, Perth, WA 6000, Australia
  • ,
  • Steven A.R. Webb, MBBS, MPH, PhD, FRACP, FJFICM

      Affiliations

    • Department of Intensive Care, Royal Perth Hospital, Perth, WA 6000, Australia
    • School of Medicine and Pharmacology, University of Western Australia, Perth, WA 6000, Australia

References 

  1. Cooper GS, Sirio CA, Rotondi AJ, et al. Are readmissions to the intensive care unit a useful measure of hospital performance?. Med Care. 1999;37:399–408
  2. Chen LM, Martin CM, Keenan SP, et al. Patients readmitted to the intensive care unit during the same hospitalization: clinical features and outcomes. Crit Care Med. 1998;26:1834–1841
  3. Rosenberg AL, Hofer TP, Hayward RA, et al. Who bounces back? Physiologic and other predictors of intensive care unit readmission. Crit Care Med. 2001;29:511–518
  4. Rosenberg AL, Watts C. Patients readmitted to ICUs: a systematic review of risk factors and outcomes. Chest. 2000;118:492–502
  5. Metnitz PG, Fieux F, Jordan B, et al. Critically ill patients readmitted to intensive care units—lessons to learn?. Intensive Care Med. 2003;29:241–248
  6. Afessa B, Keegan MT, Hubmayr RD, et al. Evaluating the performance of an institution using an intensive care unit benchmark. Mayo Clin Proc. 2005;80:174–180
  7. Duke GJ, Green JV, Briedis JH. Night-shift discharge from intensive care unit increases the mortality-risk of ICU survivors. Anaesth Intensive Care. 2004;32:697–701
  8. Kramer DJ. Intensive care unit frequent fliers: morbidity and cost. Crit Care Med. 2001;29:207–208
  9. Angus DC. Grappling with intensive care quality—does the readmission rate tell us anything?. Crit Care Med. 1998;26:1779–1780[editorial]
  10. Duke G, Santamaria J, Shann F, et al. Outcome-based clinical indicators for intensive care medicine. Anaesth Intensive Care. 2005;33:303–310
  11. The Australian Council on Healthcare Standards . ACHS clinical indicator summary guide. An approach to demonstrating the dimensions of quality. http://www.achs.org.au
  12. Chan YL, Tseng CP, Tsay PK, et al. Procalcitonin as a marker of bacterial infection in the emergency department: an observational study. Crit Care. 2004;8:R12–R20
  13. Lobo SM, Lobo FR, Bota DP, et al. C-reactive protein levels correlate with mortality and organ failure in critically ill patients. Chest. 2003;123:2043–2049
  14. Reny JL, Vuagnat A, Ract C, et al. Diagnosis and follow-up of infections in intensive care patients: value of C-reactive protein compared with other clinical and biological variables. Crit Care Med. 2002;30:529–535
  15. Alonso-Martinez JL, Llorente-Diez B, Echegaray-Agara M, et al. C-reactive protein as a predictor of improvement and readmission in heart failure. Eur J Heart Fail. 2002;4:331–336
  16. Biasucci LM, CDC , AHA . CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: application to Clinical and Public Health Practice: clinical use of inflammatory markers in patients with cardiovascular diseases: a background paper. Circulation. 2004;110:e560–e567
  17. Szklo M, Nieto FJ. In: Epidemiology: beyond the basics. Gaithersburg (Md): Aspen Publishers; 2000;p. 3–51
  18. Jewell NP. Statistics for epidemiology. In: Berkeley (Calif): Chapman & Hall/CRC; 2004;p. 43–56
  19. Ferreira FL, Bota DP, Bross A, et al. Serial evaluation of the SOFA score to predict outcome in critically ill patients. JAMA. 2001;286:1754–1758
  20. Cepeda MS, Boston R, Farrar JT, et al. Comparison of logistic regression versus propensity score when the number of events is low and there are multiple confounders. Am J Epidemiol. 2003;158:280–287
  21. Winkelmayer WC, Kurth T. Propensity scores: help or hype?. Nephrol Dial Transplant. 2004;19:1671–1673[editorial]
  22. Durbin CG, Kopel RF. A case-control study of patients readmitted to the intensive care unit. Crit Care Med. 1993;2:1547–1553
  23. BalcI C, Sungurtekin H, Gurses E, et al. Usefulness of procalcitonin for diagnosis of sepsis in the intensive care unit. Crit Care. 2003;7:85–90
  24. Luyt CE, Guerin V, Combes A, et al. Procalcitonin kinetics as a prognostic marker of ventilator-associated pneumonia. Am J Respir Crit Care Med. 2005;171:48–53
  25. Gibot S, Cravoisy A, Kolopp-Sarda MN, et al. Time-course of sTREM (soluble triggering receptor expressed on myeloid cells)-1, procalcitonin, and C-reactive protein plasma concentrations during sepsis. Crit Care Med. 2005;33:792–796
  26. Sheldon J, Riches P, Gooding R, et al. C-reactive protein and its cytokine mediators in intensive-care patients. Clin Chem. 1993;39:147–150
  27. Castelli GP, Pognani C, Meisner M, et al. Procalcitonin and C-reactive protein during systemic inflammatory response syndrome, sepsis and organ dysfunction. Crit Care. 2004;8:R234–R242
  28. Zouaoui Boudjeltia K, Piagnerelli M, Brohee D, et al. Relationship between CRP and hypofibrinolysis: is this a possible mechanism to explain the association between CRP and outcome in critically ill patients?. Thromb J. 2004;2:7
  29. Tracy RP. Inflammation in cardiovascular disease: cart, horse or both—revisited. Arterioscler Thromb Vasc Biol. 2002;22:1514–1515
  30. Devaraj S, Du T, Clos W, Jialal I. Binding and internalization of C-reactive protein by Fcgamma receptors on human aortic endothelial cells mediates biological effects. Arterioscler Thromb Vasc Biol. 2005;26:1359–1363
  31. Bisoendial RJ, Kastelein JJ, Levels JH, et al. Activation of inflammation and coagulation after infusion of C-reactive protein in humans. Circ Res. 2005;96:714–716
  32. Aujesky D, Hayoz D, Yersin B, et al. Exclusion of pulmonary embolism using C-reactive protein and D-dimer. A prospective comparison. Thromb Haemost. 2003;90:1198–1203
  33. Aviles RJ, Martin DO, Apperson-Hansen C, et al. Inflammation as a risk factor for atrial fibrillation. Circulation. 2003;108:3006–3010
  34. D'Elia JA, Weinrauch LA, Gleason RE, et al. Risk factors for thromboembolic events in renal failure. Int J Cardiol. 2005;101:19–25
  35. Fried L, Solomon C, Shlipak M, et al. Inflammatory and prothrombotic markers and the progression of renal disease in elderly individuals. J Am Soc Nephrol. 2004;15:3184–3191

 This study was performed and funded by Department of Intensive Care, Royal Perth Hospital.

PII: S0883-9441(06)00044-X

doi: 10.1016/j.jcrc.2006.01.005

Journal of Critical Care
Volume 21, Issue 3 , Pages 259-265 , September 2006