Journal of Critical Care
Volume 22, Issue 1 , Pages 26-27 , March 2007

Ventilator-associated pneumonia by multidrug-resistant bacteria: Pathogen-specific risks versus care-related risks

  • Mukadder Orhan-Sungur, MD

      Affiliations

    • Outcomes Research Institute
    • Department of Anesthesiology and Perioperative Medicine, University of Louisville, Louisville, KY 40202, USA
    • ,
  • Ozan Akça, MD

      Affiliations

    • Outcomes Research Institute
    • Department of Anesthesiology and Perioperative Medicine, University of Louisville, Louisville, KY 40202, USA
    • Neuroscience and Anesthesia Intensive Care Unit, University of Louisville, Louisville, KY 40202, USA
    • Corresponding Author InformationCorresponding author. Department of Anesthesiology and Perioperative Medicine, University of Louisville, Louisville, KY 40202, USA. Tel.: +1 502 852 5851; fax: +1 502 852 2610.
    web address

References 

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  2. Jain R, Danziger LH. Multidrug-resistant Acinetobacter infections: an emerging challenge to clinicians. Ann Pharmacother. 2004;38:1449–1459
  3. Fournier PE, Richet H. The epidemiology and control of Acinetobacter baumannii in health care facilities. Clin Infect Dis. 2006;42:692–699
  4. Murray CK, Hospenthal DR. Treatment of multidrug resistant Acinetobacter. Curr Opin Infect Dis. 2005;18:502–506
  5. Corbella X, Montero A, Pujol M, et al. Emergence and rapid spread of carbapenem resistance during a large and sustained hospital outbreak of multiresistant Acinetobacter baumannii. J Clin Microbiol. 2000;38:4086–4095
  6. Rodriguez-Bano J, Cisneros JM, Fernandez-Cuenca F, et al. Clinical features and epidemiology of Acinetobacter baumannii colonization and infection in Spanish hospitals. Infect Control Hosp Epidemiol. 2004;25:819–824
  7. Landman D, Quale JM, Mayorga D, et al. Citywide clonal outbreak of multiresistant Acinetobacter baumannii and Pseudomonas aeruginosa in Brooklyn, NY: the preantibiotic era has returned. Arch Intern Med. 2002;162:1515–1520
  8. Garnacho J, Sole-Violan J, Sa-Borges M, et al. Clinical impact of pneumonia caused by Acinetobacter baumannii in intubated patients: a matched cohort study. Crit Care Med. 2003;31:2478–2482
  9. Blot S, Vandewoude K, Colardyn F. Nosocomial bacteremia involving Acinetobacter baumannii in critically ill patients: a matched cohort study. Intensive Care Med. 2003;29:471–475
  10. Medina J, et al. Prospective study of risk factors for ventilator-associated pneumonia caused by Acinetobacter species. J Crit Care. 2006;
  11. Lortholary O, Fagon JY, Hoi AB, et al. Nosocomial acquisition of multiresistant Acinetobacter baumannii: risk factors and prognosis. Clin Infect Dis. 1995;20:790–796
  12. Fagon JY, Chastre J, Domart Y, et al. Nosocomial pneumonia in patients receiving continuous mechanical ventilation. Prospective analysis of 52 episodes with use of a protected specimen brush and quantitative culture techniques. Am Rev Respir Dis. 1989;139:877–884
  13. Villers D, Espaze E, Coste-Burel M, et al. Nosocomial Acinetobacter baumannii infections: microbiological and clinical epidemiology. Ann Intern Med. 1998;129:182–189
  14. Blot S, Vandewoude K, De Bacquer D, et al. Nosocomial bacteremia caused by antibiotic-resistant Gram-negative bacteria in critically ill patients: clinical outcome and length of hospitalization. Clin Infect Dis. 2002;34:1600–1606
  15. Carmeli Y, Troillet N, Karchmer AW, et al. Health and economic outcomes of antibiotic resistance in Pseudomonas aeruginosa. Arch Intern Med. 1999;159:1127–1132
  16. Combes A, Luyt CE, Trouillet JL. Impact of antibiotic-resistant bacteria on the outcome of ventilator-associated pneumonia. Semin Respir Crit Care Med. 2006;27:23–28
  17. Akca O, Koltka K, Uzel S, et al. Risk factors for early-onset, ventilator-associated pneumonia in critical care patients: selected multiresistant versus nonresistant bacteria. Anesthesiology. 2000;93:638–645
  18. Rello J. Bench-to-bedside review: therapeutic options and issues in the management of ventilator-associated bacterial pneumonia. Crit Care. 2005;9:259–265
  19. Ramirez J. In: Nosocomially-Acquired Pneumonia (NAP) Outcomes Performance Improvement Team Report. Louisville (Ky): University of Louisville, School of Medicine; 2006;

PII: S0883-9441(06)00122-5

doi: 10.1016/j.jcrc.2006.09.002

Journal of Critical Care
Volume 22, Issue 1 , Pages 26-27 , March 2007

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