Journal of Critical Care
Volume 22, Issue 4 , Pages 329-330 , December 2007

Corticosteroids for sepsis: Controversial forever?

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  2. Witek-Janusek L, Yelich MR. Role of the adrenal cortex and medulla in the young rats' glucoregulatory response to endotoxin. Shock. 1995;3:434–439
  3. Prigent H, Maxime V, Annane D. Science review: mechanisms of impaired adrenal function in sepsis and molecular actions of glucocorticoids. Crit Care. 2004;8:243–252
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  5. Szabo C, Thiemermann C, Wu CC, Perretti M, Vane JR. Attenuation of the induction of nitric oxide synthase by endogenous glucocorticoids accounts for endotoxin tolerance in vivo. Proc Natl Acad Sci U S A. 1994;91:271–275
  6. Bhagat K, Collier J, Vallance P. Local venous responses to endotoxin in humans. Circulation. 1996;94:490–497
  7. Bellissant E, Annane D. Effect of hydrocortisone on phenylephrine—mean arterial pressure dose-response relationship in septic shock. Clin Pharmacol Ther. 2000;68:293–303
  8. Annane D, Bellissant E, Bollaert PE, Briegel J, Keh D, Kupfer Y. Corticosteroids for treating severe sepsis and septic shock. The Cochrane Database of Systematic Reviews. 2007;[in press]
  9. Raurich JM, Llompart-Pou JA, Ibáñez J, Frontera G, Pérez O, García L, et al. Low dose steroid therapy does not affect hemodynamic response in septic shock patients. J Crit Care. 2007;
  10. Hollenberg SM, Ahrens TS, Annane D, Astiz ME, Chalfin DB, Dasta JF, et al. Practice parameters for hemodynamic support of sepsis in adult patients: 2004 update. Crit Care Med. 2004;32:1928–1948

PII: S0883-9441(07)00084-6

doi: 10.1016/j.jcrc.2007.06.001

Journal of Critical Care
Volume 22, Issue 4 , Pages 329-330 , December 2007

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