Journal of Critical Care
Volume 23, Issue 4 , Pages 513-518 , December 2008

Do proton-pump inhibitors increase the risk for nosocomial pneumonia in a medical intensive care unit?

  • Mathieu Beaulieu, MSc, MBA

      Affiliations

    • Faculty of Pharmacy, Université de Montréal, Hôpital du Sacré-Coeur de Montréal, Quebéc, Canada
    • Corresponding Author InformationCorresponding author.
    • ,
  • David Williamson, MSc, BCPS

      Affiliations

    • Faculty of Pharmacy, Université de Montréal, Hôpital du Sacré-Coeur de Montréal, Quebéc, Canada
    • Dapartment of Pharmacy, Hôpital du Sacré-Coeur de Montréal, Quebéc, Canada
    • ,
  • Carole Sirois, RN, CCRP

      Affiliations

    • Dapartment of Pharmacy, Hôpital du Sacré-Coeur de Montréal, Quebéc, Canada
    • ,
  • Jean Lachaine, PhD

      Affiliations

    • Faculty of Pharmacy, Université de Montréal, Hôpital du Sacré-Coeur de Montréal, Quebéc, Canada

References 

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  12. Mallow S, Rebuck JA, Osler T, et al. Do proton pump inhibitors increase the incidence of nosocomial pneumonia and related infectious complications when compared with histamine-2 receptor antagonists in critically ill trauma patients?. Curr Surg. 2004;61:452–458
  13. Kantorova I, Svoboda P, Scheer P, et al. Stress ulcer prophylaxis in critically ill patients: a randomized controlled trial. Hepatogastroenterology. 2004;51:757–761
  14. Levy MJ, Seelig CB, Robinson NJ, et al. Comparison of omeprazole and ranitidine for stress ulcer prophylaxis. Dig Dis Sci. 1997;42:1255–1259
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  20. Bell N, Karol MD, Sachs G, et al. Duration of effect of lansoprazole on gastric pH and acid secretion in normal male volunteers. Aliment Pharmacol Ther. 2001;15:105–113
  21. Laheij RJ, Van Ijzendoorn MC, Janssen MJ, et al. Gastric acid-suppressive therapy and community-acquired respiratory infections. Aliment Pharmacol Ther. 2003;18:847–851
  22. Gouda BB, Lydon AM, Badhe A, et al. A comparison of the effects of ranitidine and omeprazole on volume and pH of gastric contents in elective surgical patients. Eur J Anaesthesiol. 2004;21:260–264
  23. de Jonge E, Schultz MJ, Spanjaard L, et al. Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomised controlled trial. Lancet. 2003;362:1011–1016
  24. Huxley EJ, Viroslav J, Gray WR, et al. Pharyngeal aspiration in normal adults and patients with depressed consciousness. Am J Med. 1978;64:564–568
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  26. Rello J, Diaz E, Roque M, et al. Risk factors for developing pneumonia within 48 hours of intubation. Am J Respir Crit Care Med. 1999;159:1742–1746
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  28. Ibrahim EH, Tracy L, Hill C, et al. The occurrence of ventilator-associated pneumonia in a community hospital: risk factors and clinical outcomes. Chest. 2001;120:555–561
  29. Memish ZA, Cunningham G, Oni GA, et al. The incidence and risk factors of ventilator-associated pneumonia in a Riyadh hospital. Infect Control Hosp Epidemiol. 2000;21:271–273

PII: S0883-9441(07)00187-6

doi: 10.1016/j.jcrc.2007.11.003

Journal of Critical Care
Volume 23, Issue 4 , Pages 513-518 , December 2008

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