Journal of Critical Care
Volume 23, Issue 1 , Pages 64-73 , March 2008

Correlates of clinical failure in ventilator-associated pneumonia: insights from a large, randomized trial

  • Andrew F. Shorr, MD

      Affiliations

    • Pulmonary and Critical Care Medicine, Washington Hospital Center, Washington, DC, USA
    • ,
  • Deborah Cook, MD

      Affiliations

    • Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    • Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    • ,
  • Xuran Jiang, MSc

      Affiliations

    • Clinical Evaluation Research Unit, Kingston General Hospital, Kingston, Ontario, Canada
    • ,
  • John Muscedere, MD

      Affiliations

    • Clinical Evaluation Research Unit, Kingston General Hospital, Kingston, Ontario, Canada
    • Department of Medicine, Queen's University, Kingston, Ontario, Canada
    • ,
  • Daren Heyland, MD, MSc

      Affiliations

    • Clinical Evaluation Research Unit, Kingston General Hospital, Kingston, Ontario, Canada
    • Department of Medicine, Queen's University, Kingston, Ontario, Canada
    • Corresponding Author InformationCorresponding author. Tel.: +1 613 549 6666x3339; fax: +1 613 548 1351.
    • ,
  • for the Canadian Critical Care Trials Group

References 

  1. American Thoracic SocietyInfectious Diseases Society of America. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and health care-associated pneumonia. Am J Respir Crit Care Med. 2005;171(4):388–416
  2. Craven DE, Palladino R, McQuillen DP. Health care-associated pneumonia in adults: management principles to improve outcomes. Infect Dis Clin North Am. 2004;18(4):939–962
  3. Safdar N, Dezfulian C, Collard HR, et al. Clinical and economic consequences of ventilator-associated pneumonia: a systematic review. Crit Care Med. 2005;33(10):2184–2193
  4. Luna CM, Blanzaco D, Niederman MS, et al. Resolution of ventilator associated pneumonia: prospective evaluation of the clinical pulmonary infection score as an early clinical predictor of outcome. Crit Care Med. 2003;31(3):676–682
  5. Combes A, Luyt CE, Fagon JY, et al. Early predictors for infection recurrence and death in patients with ventilator-associated pneumonia. Crit Care Med. 2007;35(1):146–154
  6. Canadian Critical Care Trials Group. A randomized trial of diagnostic techniques for ventilator-associated pneumonia. N Engl J Med. 2006;355(25):2619–2630
  7. Knaus WA, Draper EA, Wagner DP, et al. APACHE II: a severity of disease classification system. Crit Care Med. 1985;13(10):818–829
  8. Marshall JC, Cook DJ, Christou NV, et al. Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med. 1995;23(10):1638–1652
  9. Singh N, Rogers P, Atwood CW, et al. Short-course empiric antibiotic therapy for patients with pulmonary infiltrates in the intensive care unit. A proposed solution for indiscriminate antibiotic prescription. Am J Respir Crit Care Med. 2000;162(2 Pt 1):505–511
  10. Dennesen PJ, van der Ven AJ, Kessels AG, et al. Resolution of infectious parameters after antimicrobial therapy in patients with ventilator-associated pneumonia. Am J Respir Crit Care Med. 2001;163(6):1371–1375
  11. Luyt CE, Guerin V, Combes A, et al. Procalcitonin kinetics as a prognostic marker of ventilator-associated pneumonia. Am J Respir Crit Care Med. 2005;171(1):48–53
  12. Montori VM, Busse JW, Permanyer-Miralda G, et al. How should clinicians interpret results reflecting the effect of an intervention on composite end points: should I dump this lump?. ACP J Club. 2005;143(3):A8

☆ Supported by grants from the Canadian Institutes of Health Research and Physicians' Services Incorporated of Ontario, and by unrestricted grants from AstraZeneca and Bayer.

PII: S0883-9441(07)00200-6

doi: 10.1016/j.jcrc.2007.11.010

Journal of Critical Care
Volume 23, Issue 1 , Pages 64-73 , March 2008

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