Journal of Critical Care
Volume 24, Issue 3 , Pages 318-321 , September 2009

Neopterin as a prognostic biomarker in intensive care unit patients

  • Terken Baydar

      Affiliations

    • Department of Toxicology, Faculty of Pharmacy, Hacettepe University, 06100 Samanpazari, Ankara, Turkey
    • Corresponding Author InformationCorresponding authors. Terken Baydar is to be contacted at Department of Toxicology, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, Samanpazari, Turkey. Tel.: +90 312 305 2178. Osman Yuksel, Department of Surgery, Faculty of Medicine, Gazi University, Besevler, Ankara, Turkey. Tel.: +90 312 202 57 28; fax: +90 312 223 05 28.
    • ,
  • Osman Yuksel

      Affiliations

    • Department of Surgery, Faculty of Medicine, Gazi University, 06500 Besevler, Ankara, Turkey
    • Corresponding Author InformationCorresponding authors. Terken Baydar is to be contacted at Department of Toxicology, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, Samanpazari, Turkey. Tel.: +90 312 305 2178. Osman Yuksel, Department of Surgery, Faculty of Medicine, Gazi University, Besevler, Ankara, Turkey. Tel.: +90 312 202 57 28; fax: +90 312 223 05 28.
    • ,
  • Tolga Tevfik Sahin

      Affiliations

    • Department of Surgery, Faculty of Medicine, Gazi University, 06500 Besevler, Ankara, Turkey
    • ,
  • Kursat Dikmen

      Affiliations

    • Department of Surgery, Faculty of Medicine, Gazi University, 06500 Besevler, Ankara, Turkey
    • ,
  • Gozde Girgin

      Affiliations

    • Department of Toxicology, Faculty of Pharmacy, Hacettepe University, 06100 Samanpazari, Ankara, Turkey
    • ,
  • Hande Sipahi

      Affiliations

    • Department of Toxicology, Faculty of Pharmacy, Hacettepe University, 06100 Samanpazari, Ankara, Turkey
    • ,
  • Osman Kurukahvecioglu

      Affiliations

    • Department of Surgery, Faculty of Medicine, Gazi University, 06500 Besevler, Ankara, Turkey
    • ,
  • Hasan Bostanci

      Affiliations

    • Department of Surgery, Faculty of Medicine, Gazi University, 06500 Besevler, Ankara, Turkey
    • ,
  • Mustafa Sare

      Affiliations

    • Department of Surgery, Faculty of Medicine, Gazi University, 06500 Besevler, Ankara, Turkey

References 

  1. Mitaka C. Clinical laboratory differentiation of infectious versus non-infectious inflammatory response syndrome. Clin Chim Acta. 2005;351:17–29
  2. In:  Cotran RS,  Kumar V,  Collins SL editor. Robbins pathologic basis of disease. 6th ed.. Philadelphia: WB Saunders Co; 1999;p. 113–138
  3. Meisner M, Tschaikowsky K, Palmaers T, et al. Comparison of procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations at different SOFA scores during the course of sepsis and MODS. Crit Care. 1999;3:45–50
  4. Hensler T, Sauerland S, Lefering R, et al. The clinical value of procalcitonin and neopterin in predicting sepsis and organ failure after major trauma. Shock. 2003;20:420–426
  5. Haupt W, Riese J, Mehler C, et al. Monocyte function before and after surgical trauma. Dig Surg. 1998;15:102–104
  6. Cinel I, Dellinger RP. Advance in pathogenesis and management of sepsis. Curr Opin Infect Dis. 2007;20:345–352
  7. Berdowska A, Zwirska-Korczala K. Neopterin measurement in clinical diagnosis. J Clin Pharm Ther. 2001;26:319–329
  8. Delogu G, Casula MA, Mancini P, et al. Serum neopterin and soluble interleukin-2 receptor for prediction of a shock state in Gram-negative sepsis. J Crit Care. 1995;10:64–71
  9. Hoffmann G, Frede S, Kenn S, et al. Neopterin-induced tumor necrosis factor-a synthesis in vascular smooth muscle cells in vitro. Int Arch Allergy Immunol. 1998;116:240–245
  10. Yao YM, Yu Y, Wang YP, et al. Elevated serum neopterin level: its relation to endotoxaemia and sepsis in patients with major burns. Eur J Clin Invest. 1996;26:224–230
  11. Murr C, Widner B, Wirleitner B, et al. Neopterin as a marker for immune system activation. Curr Drug Metab. 2002;3:175–187
  12. Ruokonen E, Ilkka L, Niskanen M, et al. Procalcitonin and neopterin as indicators of infection in critically ill patients. Acta Anaesthesiol Scand. 2002;46:398–404
  13. Knaus WA, Draper EA, Wagner DP, et al. APACHE II: a severity of disease classification system. Crit Care Med. 1985;13:818–829
  14. Sheldon J, Riches PG, Soni N, et al. Plasma neopterin as an adjunct to C-reactive protein in assessment of infection. Clin Chem. 1991;37:2038–2042
  15. Kobold ACM, Kallenberg CGM, Tervaert JWC. Monocyte activation in patients with Wegener's granulomatosis. Ann Rheum Dis. 1999;58:237–245
  16. Bjelakovic G, Jevtovic-Stoimenov T, Bjelakovic B, et al. Biochemical functions and clinical importance of unconjugated pteridines. Med Biol. 2004;11:49–54
  17. Redl H, Schlag G, Tögel E, et al. Procalcitonin release patterns in a baboon model of trauma and sepsis: relationship to cytokines and neopterin. Crit Care Med. 2000;28:3659–3663
  18. Strohmaier W, Redl H, Schlag G, et al. d-erythro-neopterin plasma levels in intensive care patients with and without septic complications. Crit Care Med. 1987;15:757–760
  19. Kaufmann P, Tilz GP, Demel U, et al. Neopterin plasma concentrations predict the course of severe acute pancreatitis. Clin Chem Lab Med. 1998;36:29–34

☆ This study was supported in part by the Hacettepe University Research Foundation (03.02.301.006) and the Gazi University Research Foundation (01/2007-74).

PII: S0883-9441(08)00150-0

doi: 10.1016/j.jcrc.2008.06.013

Journal of Critical Care
Volume 24, Issue 3 , Pages 318-321 , September 2009

Article Tools

* Image Usage & Resolution