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Journal of Critical Care
Volume 24, Issue 1
, Pages 58-65
, March 2009
The development of ultrashort acting neuromuscular relaxant tropane derivatives
References
- . Les curares a brève durée d' action.. In: Bovet D, Bovet-Nitti F, Marini-Bettolo G editor. Curare and curare like agents. Amsterdam: Elsevier Publ; 1959;p. 234–243
- . The quest for a short acting nondepolarizing neuromuscular blocking agent. Acta Anaesthesiol Scand Suppl. 1973;53:48–58
- . Synthetic inhibitors of neuromuscular transmission, chemical structures and structure-activity relationships. In: Internat Encycl Pharmacol Chapter II, Sect 14. Vol. I:Oxford: Pergamon Press; 1972;p. 243–294
- . Biodegradable neuromuscular blocking agents. I.Quaternary esters. Eur J Med Chem. 1979;14:77–84
- Biodegradable neuromuscular blocking agents. Part 4. Atracurium besylate and related polyalkylene di-esters. Eur J Med Chem. 1981;16:515–524
- Some SAR among isoquinolinium fumarate diesters leading to the identification of AV 002. In: Annual Meeting A.S.A. San Francisco A386. 2007;
- Structure: action relationships among some desacetoxy analogues of pancuronium and vecuronium in the anesthetized cat. Anesthesiology. 1988;69:57–62
- . Structure, conformation and action of neuromuscular blocking drugs. Br J Anaesth. 2001;87:755–769
- . Development of ultrashort-acting muscle relaxant agents: history, research strategies and challenges. Med Res Rev. 2005;25:610–654
- . Nicotinic ACh receptors. In: Tocris reviews series, No 28. Bristol, UK: Tocris Cookson Publ; 2007;p. 1–20
- Molecular basis of the charge selectivity of nicotinic acetylcholine receptor and related ligand-gated ion channels. Novartis Found Symp. 1999;225:215–224
- . Studies on cholinergic blocking substances II. Correlations of the antimuscarine, antinicotine and curare-like effects of mono and bisquaternary tropeines. Acta Physiol Acad Sci Hung. 1952;3:283–293
- . Non-relaxant effects of neuromuscular blocking drugs. Br J Anaesth. 1982;54:147–160
- . Effect of dose and potency on onset. Anaesth Pharmacol Rev. 1993;1:34–43
- . Calculations of octanol-water partition coefficients by fragments. Chapter 5. In: Exploring QSAR. Fundamentals and applications in chemistry and biology.. Washington, D.C.: Am Chem Society Publ; 1995;p. 125–168
- . Physicochemical properties of neuromuscular blocking agents and their impact on the pharmacokinetic-pharmacodynamic relationship. Br J Anaesth. 2004;93:241–248
- Inhibition of the enzyme degradation of suxamethonium and mivacurium increases the onset time of submaximal neuromuscular block. Anesthesiology. 1998;89:707–714
- . Possible physiological roles of carboxylic ester hydrolases. Drug Metab Rev. 1987;18:379–439
- . Competitive neuromuscular blocking agents. In: Zaimis E editors. Handb Exp. Pharmacol Vol. 42, Neuromuscular junction. Berlin: Springer; 1976;p. 421–486
- Relationship between chemical structure and physicochemical properties of series of bulky organic cations and their hepatic uptake and biliary excretion rates. J Pharmacol Exp Ther. 1997;282:715–726
- . Pharmacokinetics and pharmacodynamics of steroidal muscle relaxants. In: Partridge BL editors. Advances in the use of muscle relaxants. Philadelphia: W B Saunders Co; 1993;p. 283–307
- Speed of action of various muscle relaxants at the neuromuscular junction binding vs. buffering hypothesis. J Pharmacol Exp Ther. 1993;265:1181–1186
- Design of drugs for rapid onset. Anaesth Pharmacol Rev. 1993;1:57–89
- Structure-Pharmacokinetics relationship of series of aminosteroidal neuromuscular blocking agents in the cat. J Pharmacol Exp Ther. 2000;292:861–869
- . Pharmacology of tropane compounds in relation to their steric structure. J Pharm Pharmacol. 1957;9:209–229
- . Curare like action of decamethylene bis-(atropinium) iodide. J Pharmacol Exp Ther. 1950;98:286–292
- . Diatropine derivatives as proof that d-tubocuraraine is blocking moiety containing twin atropine-acetylcholine prosthetic groups. J Pharmacol Exp Ther. 1949;95:149–154
- . The ganglionic blocking activity of tropeines. Acta Physiol Acad Sci Hung. 1951;2:41–47
- . The ganglion blocking action of the tropine and tropinium. Acta Physiol Acad Sci Hung. 1951;2:175–177
- . Attempts to find new compounds with curare like effects. III. Quaternary derivatives of dicarboxylic acid tropine esters. Acta Chim Hung. 1952;2:369–374
- . Studies on cholinergic blocking substances III. Neuromuscular blocking tropeines. Acta Physiol Acad Sci Hung. 1953;4:159–174
- . Structure-Action relationships among derivatives of dicarboxylic acid tropine esters. Pharmacol Ther. 2002;96:1–21
- Gyermek L, Lee C, Cho YM: Neuromuscular relaxants. US Patent # 5,990.124, 1999.
- Ultrashort acting neuromuscular blocking agents, 1. Di- and trisubstituted benzyl bisquaternary ammonium tropane-3α-ol diesters. Med Chem Res. 2002;11:316–336
- . Pharmacology of G-1-64, a new nondepolarizing neuromuscular blocking agent with rapid onset and short duration of action. Acta Anaesthesiol Scand. 1999;43:651–657
- Neuromuscular pharmacology of TAAC3, a new nondepolarizing muscle relaxant with rapid onset and ultrashort duration of action. Anesth Analg. 2002;94:879–985
- Quaternary derivatives of granatanol diesters: potent, ultrashort acting non-depolarizing neuromuscular relaxants. Life Sci. 2006;79:559–569
- . The neuromuscular blocking properties of a series of bis-quaternary tropeines. Br J Pharmacol. 1960;15:71–78
- . Chemical structures of neuromuscular blocking agents. In: Agoston Bowman A, Bowman WC editor. Muscle Relaxants, Chapter 3. Amsterdam: Elsevier Science Publ; 1990;p. 59–86
- Neuromuscular blocking N,N'α-hydroxytropanium and bis-3-oxotropanium compounds. Life Sci. 1998;63:303–309
- Interim report, Organon Laboratories.
- . Conformation, action and mechanism of action of neuromuscular blocking muscle relaxants. Pharmacol Ther. 2003;98:143–169
- . Biodegradation and elimination of neuromuscular blocking agent. In: Kharkevich DA editors. New neuromuscular blocking agents, Chapter 10. Handb Exp Pharmacol. Vol. 79:Berlin: Springer Publ; 1986;p. 264–276
- . Removal of curare-like effect by direct inactivation of the myorelaxant molecule by rupturing the disulfide bond. Dokl Akad Nauk USSR. 1969;186:236–239
PII: S0883-9441(08)00181-0
doi: 10.1016/j.jcrc.2008.08.005
© 2009 Elsevier Inc. All rights reserved.
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Journal of Critical Care
Volume 24, Issue 1
, Pages 58-65
, March 2009
