Journal of Critical Care
Volume 24, Issue 1 , Pages 74-80 , March 2009

Observational study of patient-ventilator asynchrony and relationship to sedation level

  • Marjolein de Wit, MD, MS

      Affiliations

    • Division of Pulmonary Disease and Critical Care Medicine, Department of Internal Medicine, Virginia Commonwealth University, Box 980050, Richmond, VA 23298-0050, USA
    • Corresponding Author InformationCorresponding author.
    • ,
  • Sammy Pedram, MD

      Affiliations

    • Division of Pulmonary Disease and Critical Care Medicine, Department of Internal Medicine, Virginia Commonwealth University, Box 980050, Richmond, VA 23298-0050, USA
    • ,
  • Al M. Best, PhD

      Affiliations

    • Department of Biostatistics, Virginia Commonwealth University, Richmond, VA 23298-0032, USA
    • ,
  • Scott K. Epstein, MD

      Affiliations

    • Tufts University School of Medicine, Boston, MA 02111, USA

References 

  1. Thille AW, Rodriguez P, Cabello B, et al. Patient-ventilator asynchrony during mechanical ventilation: Prevalence and risk factors. Intensive Care Med. 2006;32:1515–1522
  2. Fabry B, Guttmann J, Eberhard L, et al. An analysis of desynchronization between the spontaneously breathing patient and ventilator during inspiratory pressure support. Chest. 1995;107:1387–1394
  3. Nava S, Bruschi C, Fracchia C, et al. Patient-ventilator interaction and inspiratory effort during pressure support ventilation in patients with different pathologies. Eur Respir J. 1997;10:177–183
  4. Purro A, Appendini L, De Gaetano A, et al. Physiologic determinants of ventilator dependence in long-term mechanically ventilated patients. Am J Respir Crit Care Med. 2000;161:1115–1123
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  6. Epstein SK. Optimizing patient-ventilator synchrony. Semin Respir Crit Care Med. 2001;22:137–152
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  17. de Wit M, Pedram S, Epstein SK. Relationship between patient-ventilator dyssynchrony and sedation level. Intensive Care Med. 2005;31:752;[abstr]
  18. Appendini L, Purro A, Patessio A, et al. Partitioning of inspiratory muscle workload and pressure assistance in ventilator-dependent COPD patients. Am J Respir Crit Care Med. 1996;154:1301–1309
  19. Greenblatt DJ, Gan L, Harmatz JS, et al. Pharmocokinetics and pharmacodynamics of single-dose triazolam: electroencephalography compared with the digit-symbol substitution test. Br J Clin Pharmacol. 2005;60:244–248
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☆ The study was supported with the following grants: NIH K23 GM068842 and NIH M01 RR00065; Novametrix (Wallingford, Conn) provided equipment and supplies at no cost. The granting institution is the NIH located in Bathesda, Maryland.

PII: S0883-9441(08)00193-7

doi: 10.1016/j.jcrc.2008.08.011

Journal of Critical Care
Volume 24, Issue 1 , Pages 74-80 , March 2009

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