Journal of Critical Care
Volume 23, Issue 4 , Pages 468-472 , December 2008

Hemodynamics and metabolic studies on septic shock in patients with acute liver failure

  • Ming-Hung Tsai

      Affiliations

    • Division of Gastroenterology, Chang Gung Memorial Hospital, Chang Gung University, Taipei 105, Taiwan
    • ,
  • Yung-Chang Chen

      Affiliations

    • Division of Critical Care Nephrology, Chang Gung Memorial Hospital, Chang Gung University, Taipei 105, Taiwan
    • ,
  • Jau-Min Lien

      Affiliations

    • Division of Gastroenterology, Chang Gung Memorial Hospital, Chang Gung University, Taipei 105, Taiwan
    • ,
  • Ya-Chung Tian

      Affiliations

    • Division of Critical Care Nephrology, Chang Gung Memorial Hospital, Chang Gung University, Taipei 105, Taiwan
    • ,
  • Yun-shing Peng

      Affiliations

    • Department of Internal Medicine, Chang Gung Memorial Hospital, Chia-Yi 613, Taiwan
    • ,
  • Ji-Tseng Fang

      Affiliations

    • Division of Critical Care Nephrology, Chang Gung Memorial Hospital, Chang Gung University, Taipei 105, Taiwan
    • ,
  • Chun Yang

      Affiliations

    • Division of Gastroenterology, Chang Gung Memorial Hospital, Chang Gung University, Taipei 105, Taiwan
    • ,
  • Jui-Hsiang Tang

      Affiliations

    • Division of Gastroenterology, Chang Gung Memorial Hospital, Chang Gung University, Taipei 105, Taiwan
    • ,
  • Yun-Yi Chu

      Affiliations

    • Division of Gastroenterology, Chang Gung Memorial Hospital, Chang Gung University, Taipei 105, Taiwan
    • ,
  • Pang-Chi Chen

      Affiliations

    • Division of Gastroenterology, Chang Gung Memorial Hospital, Chang Gung University, Taipei 105, Taiwan
    • ,
  • Cheng-Shyong Wu

      Affiliations

    • Division of Gastroenterology, Chang Gung Memorial Hospital, Chang Gung University, Pu-Tz City, Chia-Yi 613, Taiwan
    • Corresponding Author InformationCorresponding author. Tel.: +886 5 3621000x2005; fax: +886 3 3288662.

References 

  1. Beutler B. Innate immune sensing and the toll-like receptors. In:  Arias IM,  Boyer JL,  Chisari FV,  Fausto N,  Schachter D,  Schafritz D editor. The liver: biology and pathobiology. 4th ed.. New York: Lippincott Williams & Wilkins; 2001;p. 581–589
  2. Matuschak GM, Rinaldo JE. Organ interactions in the adult respiratory distress syndrome during sepsis: role of liver in host defense. Chest. 1988;94:400–406
  3. Sanyal AJ, Stravitz RT. Acute liver failure. In:  Zakim D,  Boyer TD editor. Hepatology: a textbook of liver disease. New York: Saunders; 2003;p. 445–496
  4. Tsai MH, Chen YC, Wu CS, et al. Extracorporal liver support with molecular adsorbents recirculating system in patients with hepatitis B-associated fulminant hepatic failure. Int J Clin Pract. 2005;59:1289–1294
  5. Groszmann RJ, Loureiro-Silva M, Tsai MH. The biology of portal hypertension. In:  Arias IM,  Boyer JL,  Chisari FV,  Fausto N,  Schachter D,  Schafritz D editor. The liver: biology and pathobiology. 4th ed.. New York: Lippincott Williams & Wilkins; 2001;p. 679–697
  6. Roreau R, Hadengue A, Soupison T, et al. Septic shock in patients with cirrhosis: hemodynamic and metabolic characteristics and intensive care unit outcome. Crit Care Med. 1992;20:746–750
  7. Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest. 1992;101:1644–1655
  8. Ganz NM, Brown RB, Berk SL, et al. In: Manual of clinical problems in infectious diseases. 4th ed.. Philadelphia: Lippincott Williams & Wilkins; 1999;p. 21–237
  9. Terra C, Guevara M, Torre A, et al. Renal failure in patients with cirrhosis and sepsis unrelated to spontaneous bacterial peritonitis: value of MELD score. Gastroenterology. 2005;129:1944–1953
  10. Dellinger RP, Carlet JM, Masur H, et al. Surviving sepsis campaign guidelines for management of severe sepsis and septic shock. Crit Care Med. 2004;32:858–873
  11. Zimmerman JE, Wagner DP, Seneff MG, et al. Intensive care unit admissions with cirrhosis: risk-stratifying patient groups and predicting individual survival. Hepatology. 1996;23:1393–1401
  12. Vincent JL, Moreno R, Takala J, et al. The SOFA (Sepsis-Related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on sepsis-related problems of the European society of intensive care medicine. Intensive Care Med. 1996;22:707–710
  13. Tsai MH, Peng YS, Lien JM, et al. Multiple organ system failure in critically ill cirrhotic patients. A comparison of two multiple organ dysfunction/failure scoring systems. Digestion. 2004;69:190–200
  14. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. Prognosis in acute organ system failure. Ann Surg. 1985;202:685–693
  15. Tsai MH, Chen YC, Ho YP, et al. Organ system failure scoring system can predict hospital mortality in critically ill cirrhotic patients. J Clin Gastroenterol. 2003;37:251–257
  16. Kamath PS, Weisner RH, Malinchoc M, et al. A model to predict survival in patients with end-stage liver disease. Hepatology. 2001;33:464–470
  17. Schmidt LE, Larsen FS. MELD score as a predictor of liver failure and death in patients with acetaminophen-induced liver injury. Hepatology. 2007;45:789–796
  18. Hung CC, Tsai YH, Lin MC, et al. Gastric intramucosal PCO2 and pH variability in ventilated critically ill patients. Crit Care Med. 2001;29:88–95
  19. Henriksen JH, Moeller S, Ring-Larsen H, Christensen NJ. The sympathetic nervous system in liver disease. J Hepatol. 1998;29:328–341
  20. Henriksen JH, Moeller S. Hemodynamics and fluid retention in liver disease. Ital J Gastroenterl Hepatol. 1998;30:320–332
  21. Ellis A, Wendon J. Circulatory, respiratory, cerebral, and renal derangements in acute liver failure: pathophysiology and management. Semin Liver Dis. 1996;16:379–388
  22. Wagner PD. Diffusive resistance to oxygen transport in muscle. Acta Physiol Scand. 2000;168:609
  23. Bakker J, Coffernils M, Leon M, et al. Blood lactate levels are superior to oxygen-derived variables in predicting outcome in septic shock. Chest. 1991;99:952–962
  24. Mizock BA. Metabolic derangements in sepsis and septic shock. Crit Care Clin. 2000;16:319–336
  25. Fink MP. Cytopathic hypoxia. Crit Care Clin. 2001;17:219–238
  26. O'Grady JG, Alexander JM, Hayllar KM, Williams R. Early indicators of prognosis in fulminant hepatic failure. Gastroenterology. 1989;97:439–445
  27. Schrier RW. Urinary indices and microscopy in sepsis-related acute renal failure. Am J Kidney Dis. 2006;48:838–841

☆ This work is partially supported by a grant from the Chang Gung Medical Research Fund CMRPG32064, Chang Gung Memorial Hospital, Taiwan.

PII: S0883-9441(08)00195-0

doi: 10.1016/j.jcrc.2008.04.006

Journal of Critical Care
Volume 23, Issue 4 , Pages 468-472 , December 2008

Article Tools