Journal of Critical Care
Volume 24, Issue 1 , Pages 29-35 , March 2009

Preclinical pharmacology of sugammadex

  • Anton Bom, MD, PhD

      Affiliations

    • Department of Pharmacology, Schering-Plough Corporation, Newhouse, ML1 5SH Scotland, United Kingdom
    • Corresponding Author InformationCorresponding author. Tel.: +44 1698 736454.
    • ,
  • Frank Hope, BSc

      Affiliations

    • Department of Pharmacology, Schering-Plough Corporation, Newhouse, ML1 5SH Scotland, United Kingdom
    • ,
  • Samantha Rutherford, PhD

      Affiliations

    • Department of Analytical Chemistry, Schering-Plough Corporation, Newhouse, ML1 5SH Scotland, United Kingdom
    • ,
  • Karen Thomson, BSc

      Affiliations

    • Department of Pharmacology, Schering-Plough Corporation, Newhouse, ML1 5SH Scotland, United Kingdom

References 

  1. Bom A, Bradley M, Cameron K, et al. A novel concept of reversing neuromuscular block: chemical encapsulation of rocuronium bromide by a cyclodextrin-based synthetic host. Angew Chem Int Ed Engl. 2002;41(2):266–270
  2. Adam JM, Bennett DJ, Bom A, et al. Cyclodextrin-derived host molecules as reversal agents for the neuromuscular blocker rocuronium bromide: synthesis and structure-activity relationships. J Med Chem. 2002;45(9):1806–1816
  3. Tarver GJ, Grove SJ, Buchanan K, et al. 2-O-substituted cyclodextrins as reversal agents for the neuromuscular blocker rocuronium bromide. Bioorg Med Chem. 2002;10(6):1819–1827
  4. Cameron KS, Clark JK, Cooper A, et al. Modified gamma-cyclodextrins and their rocuronium complexes. Org Lett. 2002;4(20):3403–3406
  5. Faria M, Oliveira L, Timóteo MA, et al. Blockade of neuronal facilitatory nicotinic receptors containing alpha3-beta2 subunits contribute to tetanic fade in the rat isolated diaphragm. Synapse. 2003;49(2):77–88
  6. Jonsson M, Gurley D, Dabrowski M, et al. Distinct pharmacologic properties of neuromuscular blocking agents on human neuronal nicotinic acetylcholine receptors: a possible explanation for the train-of-four fade. Anesthesiology. 2006;105(3):521–533
  7. Epemolu O, Bom A, Hope F, et al. Reversal of neuromuscular blockade and simultaneous increase in plasma rocuronium concentration after the intravenous infusion of the novel reversal agent Org 25969. Anesthesiology. 2003;99(3):632–637
  8. Bom A, van Egmond J, Hope F, et al. Rapid reversal of rocuronium-induced neuromuscular block by Org 25969 is independent of renal perfusion. www.asa-abstracts.com2003;[A-1158, abstr]
  9. Bom A, Mason R. Rapid reversal of profound neuromuscular block by the novel reversal agent Org 25969. Eur J Anesthesiol. 2002;19(Suppl 24):A–426[abstr]
  10. Bom A, Mason R. McIndewar I. Org 25969 causes rapid reversal of rocuronium-induced neuromuscular block, independent of acid-base status. www.asa-abstracts.com2002;[A-1009, abstr]
  11. Bom A, Hope F. A higher than required dose of sugammadex prevents the creation of a situation similar to “priming”. www.asa-abstracts.com2007;
  12. Bom A, Hope F. Sugammadex (Org 25969) can prevent neomycin-induced re-occurrence of neuromuscular block in guinea pigs. Anesth Analg. 2006;102:S-270;[abstr]
  13. Hope F, Bom A. Org 25969 reverses rocuronium-induced neuromuscular blockade in the cat without important haemodynamic effects. Eur J Anesthesiol. 2001;18(Suppl 23):17;[abstr]
  14. de Boer HD, van Egmond J, van de Pol F, et al. Time course of action of sugammadex (Org 25969) on rocuronium-induced block in the Rhesus monkey, using a simple model of equilibration of complex formation. Br J Anaesth. 2006;97(5):681–686
  15. de Boer HD, van Egmond J, van de Pol F, et al. Reversal of profound rocuronium neuromuscular blockade by sugammadex in anesthetized rhesus monkeys. Anesthesiology. 2006;104(4):718–723
  16. de Boer HD, van Egmond J, van de Pol F, et al. Sugammadex, a new reversal agent for neuromuscular block induced by rocuronium in the anaesthetized Rhesus monkey. Br J Anaesth. 2006;96(4):473–479
  17. de Boer HD, van Egmond J, van de Pol F, et al. Chemical encapsulation of rocuronium by synthetic cyclodextrin derivatives: reversal of neuromuscular block in anaesthetized Rhesus monkeys. Br J Anaesth. 2006;96(2):201–206

PII: S0883-9441(08)00233-5

doi: 10.1016/j.jcrc.2008.10.010

Journal of Critical Care
Volume 24, Issue 1 , Pages 29-35 , March 2009

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