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Journal of Critical Care
Volume 24, Issue 1
, Pages 50-57
, March 2009
Fumarates: Unique nondepolarizing neuromuscular blocking agents that are antagonized by cysteine
References
- . Does clinical anesthesia need new neuromuscular blocking agents?. Anesthesiology. 1975;42:236–239
- Berg H, Roed J, Viby Mogensen J, Mortensen CR, Engbaek J, Skovgaard LT, et al. Residual neuromuscular block is a risk factor for postoperative pulmonary complications after atracurium, vecuronium and pancuronium. Acta Anaesthesiol Scand 41:1095-1103;41.
- . Residual neuromuscular blockade and critical respiratory events in the postanesthesia care unit. Anesth Analg. 2008;107:130–137
- Bis- and mixed-tetrahydroisoquinolinium chlorofumarates: new ultra-short-acting nondepolarizing neuromuscular blockers. J Med Chem. 1999;42:206–209
- Synthesis of ultra-short-acting neuromuscular blocker GW 0430: A remarkably stereo- and regioselective synthesis of mixed tetrahydroisoquinolinium chlorofumarates. Org Lett. 1999;1:1993–1996
- Neuromuscular blocking activity and therapeutic potential effect of mixed-tetrahydroisoquinolinium halofumarates and halosuccinates in rhesus monkeys. J Med Chem. 2003;46:2502–2515
- . Solid state characterization of an neuromuscular blocking agent—GW280430A. Int J Pharm. 2002;234:19–23
- Neuromuscular blocking activity and therapeutic potential of mixed-tetrahydroisoquinolinium halofumarates and halosuccinates in rhesus monkeys. J Med Chem. 2003;46:2502–2515
- Preclinical pharmacology of GW280430A (AV430A) in the rhesus monkey and in the cat. Anesthesiology. 2004;100:835–845
- Clinical pharmacology of GW280430A in humans. Anesthesiology. 2004;100:768–773
- . Neuromuscular blocking effects of GW280430Aat the adductor pollicis and larynx in human volunteers. Br J Anaesth. 1999;82:A419
- . Edrophonium: duration of action and atropine requirements in humans during halothane anesthesia. Anesthesiology. 1982;57:261–266
- . Reversal of AV430A with cysteine in rhesus monkeys. Anesthesiology. 2004;0:A1180
- . Cardiopulmonary effects of the novel neuromuscular blocking drug GW280430A (AV430A) in dogs. Anesthesiology. 2004;100:846–851
- Glaxo Wellcome Report No. RD2000/0016/00: A novel formulation-based approach to inhibition of GW280A-induced histamine release. Submitted as part of an IND Annual Report. 09 April 2002 (Serial Np. 008).
- . Preliminary cardiovascular safety profile of AV430A in human volunteers. Anesthesiology. 2004;101:A1145
- Some SAR among isoquinolinium fumarate diesters leading to identification of AV 002. Anesthesiology. 2007;107:A386
- A promising cysteine-reversible intermediate duration neuromuscular blocker in rhesus monkeys. Anesthesiology. 2007;107:A986
- Comparative reversal of AV002 with cysteine and glutathione versus neostigmine in rhesus monkeys. Anesthesiology. 2007;107:A987
- . Continuous infusions of atracurium and vecuronium, compared with intermittent boluses of pancuronium: dose requirements and reversal. Can J Anaesth. 1992;39:925–931
- . The maximum depth of an atracurium neuromuscular block antagonized by edrophonium to effect adequate recovery. Anesthesiology. 1995;82:852–858
- The new intermediate-duration nondepolarizing relaxant AV 002 has high autonomic safety in the cat. Anesthesiology. 2007;107:A984
- Neuromuscular blocking and cardiovascular effects of ORG 9487, a new short-acting aminosteroidal blocking agent, in anesthetized animals and in isolated muscle preparations. Eur J Anesthesiol. 1998;15:467–479
- Cardiopulmonary effects of the novel neuromuscular blocking drug AV 002 in the dog. Anesthesiology. 2007;107:A983
- The hemodynamic profile of increasing doses of AV 002 in rhesus monkeys. Anestheisology. 2007;107:A387
PII: S0883-9441(08)00240-2
doi: 10.1016/j.jcrc.2008.11.001
© 2009 Elsevier Inc. All rights reserved.
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Journal of Critical Care
Volume 24, Issue 1
, Pages 50-57
, March 2009
