Journal of Critical Care
Volume 25, Issue 1 , Pages 16-22 , March 2010

Extravascular lung water to blood volume ratios as measures of pulmonary capillary permeability in nonseptic critically ill patients

  • Melanie van der Heijden, MSc

      Affiliations

    • Department of Intensive Care, Institute for Cardiovascular Research, VU University Medical Center, 1081 BT Amsterdam, The Netherlands
    • Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, 1081 BT Amsterdam, The Netherlands
    • Corresponding Author InformationCorresponding author. Department of Physiology, VU University Medical Center, 1081 BT Amsterdam, The Netherlands. Tel.: +31 20 4441790; fax: +31 20 4448255.
    • ,
  • A.B. Johan Groeneveld, MD, PhD

      Affiliations

    • Department of Intensive Care, Institute for Cardiovascular Research, VU University Medical Center, 1081 BT Amsterdam, The Netherlands

References 

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  2. Honoré PM, Jacquet LM, Beale RJ, et al. Effects of normothermia versus hypothermia on extravascular lung water and serum cytokines during cardiopulmonary bypass: a randomized, controlled trial. Crit Care Med. 2001;29:1903–1909
  3. Holm C, Tegeler J, Mayr M, et al. Effect of crystalloid resuscitation and inhalation injury on extravascular lung water: clinical implications. Chest,. 2002;121:1956–1962
  4. Sakka SG, Klein M, Reinhart K, et al. Prognostic value of extravascular lung water in critically ill patients. Chest. 2002;122:2080–2086
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  6. Martin GS, Eaton S, Mealer M, et al. Extravascular lung water in patients with severe sepsis: a prospective cohort study. Crit Care. 2005;9:R74–R82
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  8. Groeneveld AB, Verheij J. Extravascular lung water to blood volume ratios as measures of permeability in sepsis-induced ALI/ARDS. Intensive Care Med. 2006;32:1315–1321
  9. Groeneveld AB, Verheij J, van den Berg FG, et al. Increased pulmonary capillary permeability and extravascular lung water after major vascular surgery: effect on radiography and ventilatory variables. Eur J Anaesthesiol. 2006;23:36–41
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  11. Verheij J, van Lingen A, Raijmakers PG, et al. Effect of fluid loading with saline or colloids on pulmonary permeability, oedema and lung injury score after cardiac and major vascular surgery. Br J Anaesth. 2006;96:21–30
  12. Khan S, Trof RJ, Groeneveld AJ. Transpulmonary dilution-derived extravascular lung water as a measure of lung edema. Curr Opin Crit Care. 2007;13:303–307
  13. Michard F. Bedside assessment of extravascular lung water by dilution methods: temptations and pitfalls. Crit Care Med. 2007;35:1186–1192
  14. Monnet X, Anguel N, Osman D, et al. Assessing pulmonary permeability by transpulmonary thermodilution allows differentiation of hydrostatic pulmonary edema from ALI/ARDS. Intensive Care Med. 2007;33:448–453
  15. Phillips CR, Chesnutt MS, Smith SM. Extravascular lung water in sepsis-associated acute respiratory distress syndrome: indexing with predicted body weight improves correlation with severity of illness and survival. Crit Care Med. 2008;36:69–73
  16. Groeneveld AB, Raijmakers PG, Teule GJ, et al. The 67gallium pulmonary leak index in assessing the severity and course of the adult respiratory distress syndrome. Crit Care Med. 1996;24:1467–1472
  17. Sinclair DG, Braude S, Haslam PL, et al. Pulmonary endothelial injury in patients with severe lung injury. Clinical correlates and natural history. Chest. 1994;106:535–539
  18. Groeneveld AB. Radionuclide assessment of pulmonary microvascular permeability. Eur J Nucl Med. 1997;24:449–461
  19. Van der Heijden M, Verheij J, van Nieuw Amerongen GP, et al. Crystalloid or colloid fluid loading and pulmonary permeability, edema and injury in septic and non-septic critically ill patients with hypovolemia. Crit Care Med. 2009;37:[in press]
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☆ Funding: B Braun Medical, Melsungen, Germany.

PII: S0883-9441(09)00056-2

doi: 10.1016/j.jcrc.2009.02.009

Journal of Critical Care
Volume 25, Issue 1 , Pages 16-22 , March 2010

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