Journal of Critical Care
Volume 25, Issue 2 , Pages 230-235 , June 2010

Severe respiratory failure due to diffuse alveolar hemorrhage: Clinical characteristics and outcome of intensive care

  • Christian Rabe, MD, MBA

      Affiliations

    • Medical ICU, Department of Internal Medicine I, University of Bonn, D-53105 Bonn, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 228 28715507; fax: +49 228 28714698.
    • C.R. and B.A. contributed equally.
  • ,
  • Beate Appenrodt, MD

      Affiliations

    • Medical ICU, Department of Internal Medicine I, University of Bonn, D-53105 Bonn, Germany
    • C.R. and B.A. contributed equally.
  • ,
  • Christian Hoff, MD

      Affiliations

    • Medical ICU, Department of Internal Medicine II, University of Bonn, D-53105 Bonn, Germany
  • ,
  • Santiago Ewig, MD, FCCP

      Affiliations

    • Medical ICU, Department of Internal Medicine II, University of Bonn, D-53105 Bonn, Germany
    • Thoraxzentrum Ruhrgebiet, Kliniken für Pneumologie und Infektiologie, Herne und Bochum, D-44651 Herne, Germany
  • ,
  • Hans Ulrich Klehr, MD

      Affiliations

    • Medical ICU, Department of Internal Medicine I, University of Bonn, D-53105 Bonn, Germany
  • ,
  • Tilman Sauerbruch, MD

      Affiliations

    • Medical ICU, Department of Internal Medicine I, University of Bonn, D-53105 Bonn, Germany
  • ,
  • Georg Nickenig, MD

      Affiliations

    • Medical ICU, Department of Internal Medicine II, University of Bonn, D-53105 Bonn, Germany
  • ,
  • Selçuk Tasci, MD

      Affiliations

    • Medical ICU, Department of Internal Medicine II, University of Bonn, D-53105 Bonn, Germany

References 

  1. Afessa B, Tefferi A, Litzow MR, Peters SG. Outcome of diffuse alveolar hemorrhage in hematopoietic stem cell transplant recipients. Am J Respir Crit Care Med. 2002;166:1364–1368
  2. Afessa B, Tefferi A, Litzow MR, Krowka MJ, Wylam ME, Peters SG. Diffuse alveolar hemorrhage in hematopoietic stem cell transplant recipients. Am J Respir Crit Care Med. 2002;166:641–645
  3. Ioachimescu OC, Sieber S, Kotch A. Idiopathic pulmonary haemosiderosis revisited. Eur Respir. 2004;24:162–170
  4. Zandman-Goddard G, Ehrenfeld M, Levy Y, Tal S. Diffuse alveolar hemorrhage in systemic lupus erythematosus. Isr Med Assoc. 2002;4:470
  5. Zandman-Goddard G. Diffuse alveolar hemorrhage in autoimmune diseases. Isr Med Assoc. 2002;4:461–462
  6. Morelon E, Stern M, Israel-Biet D, et al. Characteristics of sirolimus-associated interstitial pneumonitis in renal transplant patients. Transplantation. 2001;72:787–790
  7. Collard HRSM. Diffuse alveolar hemorrhage. Clin Chest Med. 2004;25:583–592
  8. Hellmann MA, Gerhardt TM, Rabe C, Haas S, Sauerbruch T. Woitas RP Goodpasture's syndrome with massive pulmonary haemorrhage in the absence of circulating anti-GBM antibodies?. Nephrol Dial Transplant. 2006;21:526–529
  9. Specks U. Diffuse alveolar hemorrhage syndromes. Curr Opin Rheumatol. 2001;13:12–17
  10. De Lassence A, Fleury-Feith J, Escudier E, Beaune J, Bernaudin JF, Cordonnier C. Alveolar hemorrhage. Diagnostic criteria and results in 194 immunocompromised hosts. Am J Respir Crit Care Med. 1995;151:157–163
  11. Patel SR, Karmpaliotis D, Ayas NT, et al. The role of open-lung biopsy in ARDS. Chest. 2004;125:197–202
  12. Schwarz MI, Albert RK. “Imitators” of the ARDS: implications for diagnosis and treatment. Chest. 2004;125:1530–1535
  13. Burkhardt O, Köhnlein T, Wrenger E, Lux A, Neumann KH, Welte T. Predicting outcome and survival in patients with Wegener's granulomatosis treated on the intensive care unit. Scand J Rheumatol. 2007;36:119–124
  14. Khan SA, Subla MR, Behl D, Specks U, Afessa B. Outcome of patients with small-vessel vasculitis admitted to a medical ICU. Chest. 2007;131:972–976
  15. Khalife WI, Kogoj P, Kar B. Sirolimus-induced alveolar hemorrhage. J Heart Lung Transplant. 2007;26:652–657
  16. Vlahakis NE, Rickman OB, Morgenthaler T. Sirolimus-associated diffuse alveolar hemorrhage. Mayo Clin Proc. 2004;79:541–545
  17. Iskandar SB, Abi-Saleh B, Keith RL, Byrd RP, Roy TM. Amiodarone-induced alveolar hemorrhage. South Med J. 2006;99:383–387
  18. Kretzschmar M, Steinke K, Steinbrich W. Diffuse alveolar hemorrhage (DAH): an underestimated pulmonary complication after hematopoietic stem cell transplantation. Schweiz Rundsch Med Prax. 2005;94:1267–1269
  19. Gupta S, Jain A, Warneke CL, et al. Outcome of alveolar hemorrhage in hematopoietic stem cell transplant recipients. Bone Marrow Transplant. 2007;40:71–78
  20. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med. 2000;342:1301–1308
  21. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med. 1985;13:818–829
  22. Marshall JC, Cook DJ, Christou NV, Bernard GR, Sprung CL, Sibbald WJ. Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med. 1995;23:1638–1652
  23. Schwarz MI, Brown KK. Small vessel vasculitis of the lung. Thorax. 2000;55:502–510
  24. Costabel U. Technic and method of broncho-alveolar lavage in interstitial lung diseases. Schweiz Med Wochenschr. 1986;116:1238–1244
  25. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, et al. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med. 1994;149:818–824
  26. Gong MN, Thompson BT, Williams P, Pothier L, Boyce PD, Christiani DC. Clinical predictors of and mortality in acute respiratory distress syndrome: potential role of red cell transfusion. Crit Care Med. 2005;33:1191–1198
  27. Henke D, Falk RJ, Gabriel DA. Successful treatment of diffuse alveolar hemorrhage with activated factor VII. Ann Intern Med. 2004;140:493–494
  28. Heslet L, Nielsen JD, Levi M, Sengelov H, Johansson PI. Successful pulmonary administration of activated recombinant factor VII in diffuse alveolar hemorrhage. Crit Care. 2006;10:R177

PII: S0883-9441(09)00119-1

doi: 10.1016/j.jcrc.2009.04.009

Journal of Critical Care
Volume 25, Issue 2 , Pages 230-235 , June 2010