Journal of Critical Care
Volume 25, Issue 1 , Pages 62-68 , March 2010

Accuracy of clinical definitions of ventilator-associated pneumonia: Comparison with autopsy findings

  • Eva Tejerina, MD, PhD

      Affiliations

    • Intensive Care Unit, Hospital Universitario de Getafe, Carretera de Toledo, kilómetro 12.5, 28905 Getafe (Madrid), Spain
    • Corresponding Author InformationCorresponding author. Tel.: +34 91 6834982; fax: +34 91 6832095.
    • ,
  • Andrés Esteban, MD, PhD

      Affiliations

    • Intensive Care Unit, Hospital Universitario de Getafe, Carretera de Toledo, kilómetro 12.5, 28905 Getafe (Madrid), Spain
    • CIBER Enfermedades Respiratorias, Instituto Carlos III, (Madrid), Spain
    • ,
  • Pilar Fernández-Segoviano, MD, PhD

      Affiliations

    • Pathology Unit, Hospital Universitario de Getafe, Carretera de Toledo, 28905 Getafe (Madrid), Spain
    • ,
  • Fernando Frutos-Vivar, MD

      Affiliations

    • Intensive Care Unit, Hospital Universitario de Getafe, Carretera de Toledo, kilómetro 12.5, 28905 Getafe (Madrid), Spain
    • CIBER Enfermedades Respiratorias, Instituto Carlos III, (Madrid), Spain
    • ,
  • José Aramburu, MD

      Affiliations

    • Pathology Unit, Hospital Universitario de Getafe, Carretera de Toledo, 28905 Getafe (Madrid), Spain
    • ,
  • Daniel Ballesteros, MD

      Affiliations

    • Intensive Care Unit, Hospital Universitario de Getafe, Carretera de Toledo, kilómetro 12.5, 28905 Getafe (Madrid), Spain
    • ,
  • José María Rodríguez-Barbero, MD

      Affiliations

    • Pathology Unit, Hospital Universitario de Getafe, Carretera de Toledo, 28905 Getafe (Madrid), Spain

References 

  1. Meduri GU, Mauldin GL, Wunderink RG, Leeper KV, Jones CB, Tolley E, et al. Causes of fever and pulmonary densities in patients with clinical manifestations of ventilator-associated pneumonia. Chest. 1994;106:221–223
  2. Wunderink RG, Woldenberg LS, Zeiss J, Day CM, Ciemins J, Lacher DA. The radiologic diagnosis of autopsy-proven ventilator-associated pneumonia. Chest. 1992;101:458–463
  3. Torres A, el-Ebiary M, Padró L, Gonzalez J, de la Bellacasa JP, Ramirez J, et al. Validation of different techniques for the diagnosis of ventilator-associated pneumonia. Comparison with immediate postmortem pulmonary biopsy. Am J Respir Crit Care Med. 1994;149:324–331
  4. Marquette CH, Copin MC, Wallet F, Neviere R, Saulnier F, Mathieu D, et al. Diagnostic tests for pneumonia in ventilated patients: prospective evaluation of diagnostic accuracy using histology as a diagnostic gold standard. Am J Respir Crit Care Med. 1995;151:1878
  5. Kirtland SH, Corley DE, Winterbauer RH, Springmeyer SC, Casey KR, Hampson NB, et al. The diagnosis of ventilator-associated pneumonia. A comparison of histologic, microbiologic, and clinical criteria. Chest. 1997;112:445–457
  6. Fàbregas N, Ewig S, Torres A, El-Ebiary M, Ramirez J, de la Bellacasa JP, et al. Clinical diagnosis of ventilator associated pneumonia revisited: comparative validation using immediate post-mortem lung biopsies. Thorax. 1999;54:867–873
  7. Fagon JY, Chastre J, Hance AJ, Domart Y, Trouillet JL, Gilbert C. Evaluation of clinical judgement in the identification and treatment of nosocomial pneumonia in ventilated patients. Chest. 1993;103:547–553
  8. Johanson WG, Pierce AK, Sandford JP, Thomas GD. Nosocomial respiratory infections with gram-negative bacilli: the significance of colonization of the respiratory tract. Ann Intern Med. 1972;77:701–706
  9. Pugin J, Auckenthaler R, Mili N, Janssens P, Lew D, Suter PM. Diagnosis of ventilator-associated pneumonia by bacteriologic analysis of bronchoscopic and nonbronchospic “blind” bronchoalveolar lavage fluid. Am Rev Respir Dis. 1991;143:1121–1129
  10. Fernandez-Segoviano P, Lázaro A, Esteban A, Rubio JM, Iruretagoyena JR. Autopsy as quality assurance in the intensive care unit. Crit Care Med. 1988;16:683–685
  11. Jaeschke R, Guyatt G, Sackett DL. Users' guides to the medical literature. III. How to use an article about a diagnostic test. Are the results of the study valid? Evidence-Based Medicine Working Group. JAMA. 1994;271:389–391
  12. Agresti A. Analysis of Ordinal Categorical Data. New York: John Wiley; 1984;
  13. Deeks JJ. Systematic reviews of evaluations of diagnostic and screening tests. In:  Egger M,  Smith GD editor. Systematic Reviews in Health Care. Meta-Analysis in Context. London: BMJ Books; 2001;p. 248–282
  14. Zamora J, Muriel A, Abraira V. Meta-Disc for Windows: A Software Package for the Meta-Analysis of Diagnostic Test. Accessed at: www.hrc.es/investigacion/metadisc.htmlon 17 November 2007
  15. Meade MO, Cook RJ, Guyatt GH, et al. Interobserver variation in interpreting chest radiographs for the diagnosis of acute respiratory distress syndrome. Am J Respir Crit Care Med. 2000;161:85–90
  16. Richeldi L, Mariani M, Losi M, Maselli F, Corbetta L, Buonsanti C, et al. Triggering receptor expressed on myeloid cells: role in the diagnosis of lung infections. Eur Respir J. 2004;24:247–250
  17. Gibot S, Cravoisy A, Levy B, Bene MC, Faure G, Bollaert PE. Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia. N Engl J Med. 2004;350:451–458

PII: S0883-9441(09)00121-X

doi: 10.1016/j.jcrc.2009.05.008

Journal of Critical Care
Volume 25, Issue 1 , Pages 62-68 , March 2010

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