Journal of Critical Care
Volume 25, Issue 2 , Pages 225-229, June 2010

Risk factors and outcome of acute renal failure in patients with severe acute pancreatitis☆

  • Hao Li, MD

      Affiliations

    • Department of Emergency, Hunan Provincial People's Hospital, Changsha 410002, China
    • ,
  • Zhaoxin Qian, MD

      Affiliations

    • Department of Emergency, Xiangya Hospital, Central South University, Changsha 410008, China
    • Corresponding Author InformationCorresponding author. Tel.: +86 0731 4327098; fax: +86 0731 4327329.
    • ,
  • Zhiling Liu, MD

      Affiliations

    • Department of Emergency, Hunan Provincial People's Hospital, Changsha 410002, China
    • ,
  • Xiaoliang Liu, MD

      Affiliations

    • Department of Emergency, Hunan Provincial People's Hospital, Changsha 410002, China
    • ,
  • Xiaotong Han, MD

      Affiliations

    • Department of Emergency, Hunan Provincial People's Hospital, Changsha 410002, China
    • ,
  • Hong Kang, MD

      Affiliations

    • Department of Emergency, Hunan Provincial People's Hospital, Changsha 410002, China

published online 25 September 2009.

Abstract 

Objective

Acute renal failure (ARF) is one of the most common causes of death in patients with severe acute pancreatitis (SAP). Here, we aimed to investigate the risk factors of ARF in patients with SAP, assess the prognosis of patients with SAP and ARF, and seek potential measures to prevent ARF.

Method

A cross-sectional study was performed to analyze the data from patients with SAP. Both univariate and multivariate logistic regression analyses were performed, including 15 indices such as age, history of renal disease, Acute Physiology and Chronic Health Evaluation II scores, hypoxemia, abdominal compartment syndrome (ACS), and others. Univariate analysis was also used to compare the prognosis between the groups of patients with SAP with and without ARF.

Results

There was a significant difference in age, history of renal disease, Acute Physiology and Chronic Health Evaluation II scores, hypoxemia, and ACS between the groups with and without ARF. Patients with SAP and ARF had significantly longer average length of stay and intensive care unit length of stay and higher infection rate of the pancreas and mortality rate.

Conclusion

The significant risk factors for ARF in patients with SAP include history of renal disease, hypoxemia, and ACS. Measures that can prevent ARF include homeostasis maintenance, adequate perfusion of the kidneys, adequate oxygenation, and abdominal decompression to avoid ACS.

Keywords: Acute renal failure, Severe acute pancreatitis, History of renal disease, hypoxemia, Abdominal compartment syndrome

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☆ There is no conflict of interest in the study.

PII: S0883-9441(09)00223-8

doi:10.1016/j.jcrc.2009.07.009

Journal of Critical Care
Volume 25, Issue 2 , Pages 225-229, June 2010

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