Mechanical ventilation mode (volume × pressure) does not change the variables obtained by indirect calorimetry in critically ill patients

Clapis, Franciele C. Meireles; Auxiliadora-Martins, Maria; Japur, Camila Cremonezi; Martins-Filho, Olindo Assis; Évora, Paulo Roberto Barbosa; Basile-Filho, Anibal

doi:10.1016/j.jcrc.2009.11.010

« Previous Next »Journal of Critical Care
Volume 25, Issue 4 , Pages 659.e9-659.e16, December 2010

Mechanical ventilation mode (volume × pressure) does not change the variables obtained by indirect calorimetry in critically ill patients☆

Franciele C. Meireles Clapis, MS
- Divisão de Terapia Intensiva, Departamento de Cirurgia e Anatomia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, 14049-900 Ribeirão Preto, SP, Brazil
Maria Auxiliadora-Martins, MD, PhD
- Divisão de Terapia Intensiva, Departamento de Cirurgia e Anatomia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, 14049-900 Ribeirão Preto, SP, Brazil
- Corresponding author. Centro de Terapia Intensiva-Campus, Faculdade de Medicina de Ribeirão Preto-USP, 3900, 14049-900 Ribeirão Preto, SP, Brazil. Fax: +55 16 36022439.
Camila Cremonezi Japur, MS
- Divisão de Terapia Intensiva, Departamento de Cirurgia e Anatomia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, 14049-900 Ribeirão Preto, SP, Brazil
Olindo Assis Martins-Filho, PhD
- Laboratório de Biomarcadores de Diagnóstico e Monitoração, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz-Minas, 30190-002 Belo Horizonte, MG, Brazil
Paulo Roberto Barbosa Évora, MD, PhD
- Divisão de Terapia Intensiva, Departamento de Cirurgia e Anatomia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, 14049-900 Ribeirão Preto, SP, Brazil
Anibal Basile-Filho, MD, PhD
- Divisão de Terapia Intensiva, Departamento de Cirurgia e Anatomia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, 14049-900 Ribeirão Preto, SP, Brazil

published online 18 January 2010.

Abstract

Purpose

The aim of the study was to analyze the difference between the results obtained by indirect calorimetry (IC) using volume-controlled and pressure-controlled mechanical ventilation in 2 different ventilators and to characterize the variables achieved by IC after well-defined changes in minute volume (Vm).

Materials and Methods

Prospective study of 20 critically ill patients under volume-controlled (n = 15) or pressure-controlled (n = 5) mechanical ventilation. Three IC measurements of 45 minutes each were taken; values of oxygen consumption (Vo₂), carbon dioxide production (Vco₂), Vm, resting energy expenditure (REE), and respiratory quotient (RQ) were obtained. For the last measurement, Vm was set at 20% above the baseline.

Results

There were no differences between the results obtained by IC during volume-controlled and pressure-controlled mechanical ventilation. The most relevant changes in the variables obtained by IC before and after intervention in Vm were a significant increase in Vco₂ (from 165 to 177 mL·min⁻¹; P < .01), a decrease in Paco₂ (from 38.49 to 28.46 mm Hg; P < .01), and a rise in pH (from 7.41 to 7.49; P < .01). There were no alterations in Vo₂, REE, or RQ.

Conclusions

Ventilators and ventilation modes do not influence the IC measurements. The observed changes have no clinical effects and are reversible, provided that increased Vm is maintained for no longer than 45 minutes.

Keywords: Indirect calorimetry, Mechanical ventilation, ICU setting, Vo₂, Vco₂