Journal of Critical Care
Volume 25, Issue 3 , Pages 542.e1-542.e8 , September 2010

Polymorphisms of genes encoding tumor necrosis factor-alpha, interleukin-10, cluster of differentiation-14 and interleukin-1ra in critically ill patients

  • Maja Surbatovic

      Affiliations

    • Clinic of Anesthesiology and Intensive Therapy, Military Medical Academy, 11000 Belgrade, Serbia
    • Corresponding Author InformationCorresponding author. Tel.: +381 11 2665 125; fax: +381 11 2665 125.
    • ,
  • Krasimirka Grujic

      Affiliations

    • Anesthesia and Critical Care Department, Clinical Center, 38220 Kosovska Mitrovica, Serbia
    • ,
  • Bojana Cikota

      Affiliations

    • Institute for Medical Research, Military Medical Academy, 11000 Belgrade, Serbia
    • ,
  • Miodrag Jevtic

      Affiliations

    • Clinic of General and Vascular Surgery, Military Medical Academy, 11000 Belgrade, Serbia
    • ,
  • Nikola Filipovic

      Affiliations

    • Clinic of Anesthesiology and Intensive Therapy, Military Medical Academy, 11000 Belgrade, Serbia
    • ,
  • Predrag Romic

      Affiliations

    • Clinic of Anesthesiology and Intensive Therapy, Military Medical Academy, 11000 Belgrade, Serbia
    • ,
  • Natasa Strelic

      Affiliations

    • Institute for Medical Research, Military Medical Academy, 11000 Belgrade, Serbia
    • ,
  • Zvonko Magic

      Affiliations

    • Institute for Medical Research, Military Medical Academy, 11000 Belgrade, Serbia

References 

  1. Jean-Baptiste E. Cellular mechanism in sepsis. J Intensive Care Med. 2007;22:63–72
  2. Sorensen TI, Nielsen GG, Andersen PK, et al. Genetic and environmental influences on premature death in adult adoptees. N Engl J Med. 1988;318:727–732
  3. Read RC, Teare DM, Pridmore AC, et al. The tumor necrosis factor polymorphism TNF (-308) is associated with susceptibility to meningococcal sepsis, but not with lethality. Crit Care Med. 2009;37:1237–1243
  4. De Maio A, Torres MB, Reeves RH. Genetic determinants influencing the response to injury, inflammation and sepsis. Shock. 2005;23:11–17
  5. Ledoux D, Canivet JL, Preiser JC, et al. SAPS 3 admission score: an external validation in general intensive care population. Intensive Care Med. 2008;34:1873–1877
  6. Le Gall JR, Lemeshow S, Saulnier F. A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. JAMA. 1993;270:2957–2963
  7. Knaus WA, Draper EA, Wagner DP, et al. APACHE II: a severity of disease classification system. Crit Care Med. 1985;13:818–829
  8. Moreno RP, Vincent JL, Matos R, et al. The use of maximum SOFA score to quantify organ dysfunction/failure in intensive care. Results of a prospective multicentre study. Intensive Care Med. 1999;25:686–696
  9. Tang GJ, Huang SL, Yien HW, et al. Tumor necrosis factor gene polymorphism and septic shock in surgical infection. Crit Care Med. 2000;28:2733–2736
  10. Gibot S, Cariou A, Drouet L, et al. Association between a genomic polymorphism within the CD14 locus and septic shock susceptibility and mortality rate. Crit Care Med. 2002;30:969–973
  11. Witkin SS, Gerber S, Ledger J. Influence of interleukin-1 receptor antagonist gene polymorphism on disease. CID. 2002;34:204–209
  12. Gordon AC, Lagan AL, Aganna E, et al. TNF and TNFR polymorphisms in severe sepsis and septic shock: a prospective multicenter study. Genes Immun. 2004;5:631–640
  13. Mira JP, Cariou A, Grall F, et al. Association of TNF2, TNF-α promoter polymorphism, with septic shock susceptibility and mortality. A multicenter study. JAMA. 1999;282:561–568
  14. O'Keefe GE, Hybki DL, Munford RS. The G → A single nucleotide polymorphism at the -308 position in the tumor necrosis factor alpha promoter increases the risk for severe sepsis after trauma. J Trauma. 2002;52:817–825
  15. Watanabe E, Hirasawa H, Oda S, et al. Extremely high interleukin-6 blood levels and outcome in the critically ill are associated with tumor necrosis factor- and interleukin-1–related gene polymorphisms. Crit Care Med. 2005;33:89–97
  16. Barber RC, Aragaki CC, Rivera-Chavez FA, et al. TLR4 and TNF-α polymorphisms are associated with an increased risk for severe sepsis following burn injury. J Med Genet. 2004;41:808–813
  17. Reid CL, Perrey C, Pravica V, et al. Genetic variation in proinflammatory and anti-inflammatory cytokine production in multiple organ dysfunction syndrome. Crit Care Med. 2002;30:2216–2221
  18. Dianliang Z, Lieshou L, Zhiwei J, et al. Association of plasma levels of tumor necrosis factor (TNF)-α and its soluble receptors, two polymorphisms of the TNF gene with acute severe pancreatitis and early septic shock due to it. Pancreas. 2003;26:339–343
  19. Powell JJ, Fearon KC, Siriwardena AK, et al. Evidence against a role for polymorphisms at tumor necrosis factor, interleukin-1 and interleukin-1-receptor antagonist gene loci in the regulation of disease severity in acute pancreatitis. Surgery. 2001;129:633–640
  20. Waterer GW, Wunderink RG. Science review: genetic variability in the systemic inflammatory response. Crit Care. 2003;7:308–314
  21. Papachristou GI, Clermont G, Sharma A, et al. Risk and markers of severe acute pancreatitis. Gastroenterol Clin North Am. 2007;36:277–296
  22. Zhang DL, Zheng HM, Yu BJ, et al. Association of polymorphisms of IL and CD14 genes with acute severe pancreatitis and septic shock. World J Gastroenterol. 2005;11:4409–4413
  23. Sabelnikovs O, Nikitina-Zake L, Zhuravlova J, et al. Association of IL-10 promoter polymorphism -1082 G/A with adverse outcome in severe sepsis and septic shock. Crit Care. 2009;13(Suppl. 1):P355;(abstr)
  24. Stanilova SA, Miteva LD, Karakolev ZT, et al. Interleukin-10-1082 promoter polymorphism in association with cytokine production and sepsis susceptibility. Intensive Care Med. 2006;32:260–266
  25. Schaaf BM, Boehmke F, Esnaashari H, et al. Pneumococcal septic shock is associated with the interleukin-10-1082 gene promoter polymorphism. Am J Respir Crit Care Med. 2003;168:476–480
  26. Shu Q, Fang X, Chen Q, et al. IL-10 polymorphism is associated with increased incidence of severe sepsis. Chin Med J. 2003;116:1756–1759
  27. Gong MN, Thompson BT, Williams PL, et al. Interleukin-10 polymorphism in position -1082 and acute respiratory distress syndrome. Eur Respir J. 2006;27:674–681
  28. Sutherland AM, Walley KR, Russell JA. Polymorphisms in CD14, mannose-binding lectin, and Toll-like receptor 2 are associated with increased prevalence of infection in critically ill adults. Crit Care Med. 2005;33:638–644
  29. Yuan FF, Marks K, Wong M, et al. Clinical relevance of TLR2, TLR4, CD14 and FcγRIIA gene polymorphisms in Streptococcus pneumoniae infection. Immunol Cell Biol. 2008;86:268–270
  30. Agnese DM, Calvano JE, Hahm SJ, et al. Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of Gram-negative infections. J Infect Dis. 2002;186:1522–1525
  31. Hubacek JA, Stuber F, Frohlich D, et al. The common functional C(-159)T polymorphism within the promoter region of the lipopolysaccharide receptor CD14 is not associated with sepsis development or mortality. Genes Immun. 2000;1:405–407
  32. Nakada T, Hirasawa H, Oda S, et al. Influence of toll-like receptor 4, CD14, tumor necrosis factor and interleukin-10 gene polymorphisms on clinical outcome in Japanese critically Ill patients. J Surg Res. 2005;129:322–328
  33. Gu W, Dong H, Jiang DP, et al. Functional significance of CD14 promoter polymorphisms and their clinical relevance in a Chinese Han population. Crit Care Med. 2008;36:2274–2280
  34. Fang XM, Schroder S, Hoeft A, et al. Comparison of two polymorphisms of the interleukin-1 gene family: interleukin-1 receptor antagonist polymorphism contributes to susceptibility to severe sepsis. Crit Care Med. 1999;27:1330–1334
  35. Arnalich F, Lopez-Maderuelo D, Codoceo R, et al. Interleukin-1 receptor antagonist gene polymorphism and mortality in patients with severe sepsis. Clin Exp Immunol. 2002;127:331–336
  36. Ma P, Chen D, Pan J, et al. Genomic polymorphism within interleukin-1 family cytokines influences the outcome of septic patients. Crit Care Med. 2002;30:1046–1050

PII: S0883-9441(10)00003-1

doi: 10.1016/j.jcrc.2009.12.003

Journal of Critical Care
Volume 25, Issue 3 , Pages 542.e1-542.e8 , September 2010

Article Tools

* Image Usage & Resolution