Journal of Critical Care
Volume 25, Issue 3 , Pages 458-462 , September 2010

Intravenous paracetamol reduced the use of opioids, extubation time, and opioid-related adverse effects after major surgery in intensive care unit

  • Dilek Memis, MD

      Affiliations

    • Medical Faculty, Department of Anesthesiology and Reanimation, Trakya University, 22030 Edirne, Turkey
    • Corresponding Author InformationCorresponding author. Fax: +90 284 235 80 96.
    • ,
  • Mehmet Turan Inal, MD

      Affiliations

    • Medical Faculty, Department of Anesthesiology and Reanimation, Trakya University, 22030 Edirne, Turkey
    • ,
  • Gulsum Kavalci, MD

      Affiliations

    • Medical Faculty, Department of Anesthesiology and Reanimation, Trakya University, 22030 Edirne, Turkey
    • ,
  • Atakan Sezer, MD

      Affiliations

    • Medical Faculty, Department of General Surgery, Trakya University, 22030 Edirne, Turkey
    • ,
  • Necdet Sut, PhD

      Affiliations

    • Medical Faculty, Department of Biostatistic, Trakya University, 22030 Edirne, Turkey

References 

  1. Puig MM, Montes A, Marrugat J. Management of postoperative pain in Spain. Acta Anaesthesiol Scand. 2001;45:465–470
  2. Kehlet H, Dahl JB. The value of “multimodal” or “balanced analgesia” in postoperative pain treatment. Anesth Analg. 1993;77:1048–1056
  3. Pickering G, Loriot MA, Libort F, et al. Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism. Clin Pharmacol Ther. 2006;79:371–378
  4. Bannwarth B, Pehourcq F. Pharmacologic basis for using paracetamol: pharmacokinetic and pharmacodynamic issues. Drugs. 2003;63:5–13
  5. Lahtinen P, Kokki H. Propacetamol as adjunctive treatment for postoperative pain after cardiac surgery. Anesth Analg. 2002;95:813–819
  6. Aissaoui Y, Zeggwagh AA, Zekraoui A, Abidi K, Abouqal R. Validation of a behavioral pain scale in critically ill, sedated, and mechanically ventilated patients. Anesth Analg. 2005;101:1470–1476
  7. Payen JF, Bru O, Bosson JL, et al. Assessing pain in critically ill sedated patients by using a behavioral pain scale. Crit Care Med. 2001;29:2258–2263
  8. Chanques G, Jaber S, Barbotte E, et al. Impact of systematic evaluation of pain and agitation in an intensive care unit. Crit Care Med. 2006;34:1691–1699
  9. Grounds RM, Lalor JM, Lumley J, Royston D, Morgan M. Propofol infusion for sedation in the intensive care unit: preliminary report. Br Med J. 1987;294:397–400
  10. Chung F, Ritchie E, Su J. Postoperative pain in ambulatory surgery. Anesth Analg. 1997;85:808–816
  11. Dahl JB, Rosenberg J, Dirkes WE, Mogensen T, Kehlet H. Prevention of postoperative pain by balanced analgesia. Br J Anaesth. 1990;64:518–520
  12. Paul WF. The changing role of non-opioid analgesic techniques in the management of postoperative pain. Anesth Analg. 2005;101:S5–S22
  13. Eriksson H, Tenhunen A, Korttila K. Balanced analgesia improves recovery and outcome after outpatient tubal ligation. Acta Anaesthesiol Scand. 1996;40:151–155
  14. Cashman J, McAnulty G. Nonsteroidal anti-inflammatory drugs in perisurgical pain management. Mechanisms of action and rationale for optimum use. Drugs. 1995;49:51–70
  15. Bannwarth B, Demotes-Mainard F, Schaeverbeke T, Labat L, Dehais J. Central analgesic effects of aspirin-like drugs. Fundam Clin Pharmacol. 1995;9:1–7
  16. Björkman R. Central antinociceptive effects of non-steroidal anti-inflammatory drugs and paracetamol. Experimental studies in the rat. Acta Anaesthesiol Scand Suppl. 1995;103:1–44
  17. Björkman R, Hallman KM, Hedner J, Hedner T, Henning M. Acetaminophen blocks spinal hyperalgesia induced by NMDA and substance P. Pain. 1994;57:259–264
  18. Remy C, Marret E, Bonnet F. Effects of acetaminophen on morphine side-effects and consumption after major surgery: meta-analysis of randomized controlled trials. Br J Anaesth. 2005;4:505–513
  19. Aubrun F, Kalfon F, Mottet P, et al. Adjunctive analgesia with intravenous propacetamol does not reduce morphine-related adverse effects. Br J Anaesth. 2003;90:314–319
  20. Peduto VA, Ballabio M, Stefanini S. Efficacy of propacetamol in the treatment of postoperative pain. Morphine-sparing effect in orthopedic surgery. Italian Collaborative Group on Propacetamol. Acta Anaesthesiol Scand. 1998;42:293–298
  21. Hernandez-Palazon J, Tortosa JA, Martinez-Lage JF, Perez-Flores D. Intravenous administration of propacetamol reduces morphine consumption after spinal fusion surgery. Anesth Analg. 2001;92:1473–1476
  22. Kehlet H, Rung GW, Callesen T. Postoperative opioid analgesia: time for a reconsideration. J Clin Anesth. 1996;8:441–445
  23. Kehlet H, Werner MU. Role of paracetamol in acute pain management. Drugs. 2003;63(Suppl 2):15–21
  24. Grundmann U, Wörnle C, Biedler A, et al. The efficacy of the non-opioid analgesics parecoxib, paracetamol and metamizol for postoperative pain relief after lumbar microdiskectomy. Anesth Analg. 2006;103:217–222
  25. Remy C, Marret E, Bonnet F. State of art of paracetamol in acute pain therapy. Curr Opin Anaesthesiol. 2006;19:562–565

☆ European Society of Intensive Care Medicine Congress, Vienna, Austria, 519, 11-14 October 2009—poster.

PII: S0883-9441(10)00012-2

doi: 10.1016/j.jcrc.2009.12.012

Journal of Critical Care
Volume 25, Issue 3 , Pages 458-462 , September 2010

Article Tools