Journal of Critical Care
Volume 25, Issue 2 , Pages 358.e1-358.e7 , June 2010

The effects of methylene blue infusion on gastric tonometry and intestinal fatty acid binding protein levels in septic shock patients

  • Frank M.P. van Haren

      Affiliations

    • Intensive Care Department, Waikato Hospital, Hamilton 3240, New Zealand
    • Corresponding Author InformationCorresponding author. Intensive Care Department, Waikato Hospital, Hamilton, New Zealand. Tel.: +64 7 8398899; fax: +64 7 839 8912.
    • ,
  • Peter Pickkers

      Affiliations

    • Intensive Care Department, Radboud University Nijmegen Medical Centre, Nijmegen 6500 HB, The Netherlands
    • ,
  • Norbert Foudraine

      Affiliations

    • Intensive Care Department, VieCuri Medical Centre, Venlo 5912 BL, The Netherlands
    • ,
  • Suzanne Heemskerk

      Affiliations

    • Intensive Care Department, Radboud University Nijmegen Medical Centre, Nijmegen 6500 HB, The Netherlands
    • Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen 6500 HB, The Netherlands
    • ,
  • James Sleigh

      Affiliations

    • Intensive Care Department, Waikato Hospital, Hamilton 3240, New Zealand
    • ,
  • Johannes G. van der Hoeven

      Affiliations

    • Intensive Care Department, Radboud University Nijmegen Medical Centre, Nijmegen 6500 HB, The Netherlands

  • Image Result

    Box plots of median arterial pressure (A), norepinephrine infusion rate (B), CI (C), and extravascular lung water index (D) before, during and after MB infusion. *P = .04; **P = .02.

    Box plots of median arterial pressure (A), norepinephrine infusion rate (B), CI (C), and extravascular lung water index (D) before, during and after MB infusion. *P = .04; **P = .02.

  • Image Result

    Box plots of median P(g-a)CO2 gap in septic shock in all patients (A) and in patients with normal and elevated baseline P(g-a)CO2 gap (B) before, during, and after 4 hours of MB infusion. *P = .012.

    Box plots of median P(g-a)CO2 gap in septic shock in all patients (A) and in patients with normal and elevated baseline P(g-a)CO2 gap (B) before, during, and after 4 hours of MB infusion. *P = .012.

☆ The authors disclose no conflict of interest.

☆☆ The study was performed at the Intensive Care Department, VieCuri Medical Centre, Venlo, The Netherlands.

★ Trial registration at Australian New Zealand Clinical Trials Registry (www.anzctr.org.au). Registration number ACTRN12608000090314

PII: S0883-9441(10)00063-8

doi: 10.1016/j.jcrc.2010.02.008

Journal of Critical Care
Volume 25, Issue 2 , Pages 358.e1-358.e7 , June 2010

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