Journal of Critical Care
Volume 26, Issue 3 , Pages 249-256 , June 2011

Alveolar fluid clearance is faster in women with acute lung injury compared to men

  • Julie A. Bastarache, MD

      Affiliations

    • Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-2650, USA
    • Corresponding Author InformationCorresponding author.
  • ,
  • Thida Ong, MD

      Affiliations

    • Department of Pediatrics, University of California, San Francisco, CA 94143, USA
  • ,
  • Michael A. Matthay, MD

      Affiliations

    • Departments of Medicine & Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
  • ,
  • Lorraine B. Ware, MD

      Affiliations

    • Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-2650, USA

References 

  1. Agarwal R, Aggarwal AN, Gupta D, Behera D, Jindal SK. Etiology and outcomes of pulmonary and extrapulmonary acute lung injury/ARDS in a respiratory ICU in North India. Chest. 2006;130(3):724–729
  2. Moss M, Mannino DM. Race and gender differences in acute respiratory distress syndrome deaths in the United States: an analysis of multiple-cause mortality data (1979- 1996). Crit Care Med. 2002;30(8):1679–1685
  3. Perelman RH, Palta M, Kirby R, Farrell PM. Discordance between male and female deaths due to the respiratory distress syndrome. Pediatrics. 1986;78(2):238–244
  4. Choi CW, Kim BI, Park JD, Koh YY, Choi JH, Choi JY. Risk factors for the different types of chronic lung diseases of prematurity according to the preceding respiratory distress syndrome. Pediatr Int. 2005;47(4):417–423
  5. Rubenfeld GD, Caldwell E, Peabody E, Weaver J, Martin DP, Neff M, et al. Incidence and outcomes of acute lung injury. N Engl J Med. 2005;353(16):1685–1693
  6. Cooke CR, Kahn JM, Caldwell E, Okamoto VN, Heckbert SR, Hudson LD, et al. Predictors of hospital mortality in a population-based cohort of patients with acute lung injury. Crit Care Med. 2008;36(5):1412–1420
  7. Gong MN, Wei Z, Xu LL, Miller DP, Thompson BT, Christiani DC. Polymorphism in the surfactant protein-B gene, gender, and the risk of direct pulmonary injury and ARDS. Chest. 2004;125(1):203–211
  8. Sheu CC, Zhai R, Su L, Tejera P, Gong MN, Thompson BT, et al. Sex-specific association of epidermal growth factor gene polymorphisms with acute respiratory distress syndrome. Eur Respir J. 2009;33(3):543–550
  9. Cooke CR, Shah CV, Gallop R, Bellamy S, Ancukiewicz M, Eisner MD, et al. A simple clinical predictive index for objective estimates of mortality in acute lung injury. Crit Care Med. 2009;37(6):1913–1920
  10. Brun-Buisson C, Minelli C, Bertolini G, Brazzi L, Pimentel J, Lewandowski K, et al Epidemiology and outcome of acute lung injury in European intensive care units. Results from the ALIVE study. Intensive Care Med. 2004;30(1):51–61
  11. Ware LB, Matthay MA. Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome. Am J Respir Crit Care Med. 2001;163(6):1376–1383
  12. Matthay MA, Wiener-Kronish JP. Intact epithelial barrier function is critical for the resolution of alveolar edema in humans. Am Rev Respir Dis. 1990;142(6 Pt 1):1250–1257
  13. Matthay MA, Folkesson HG, Clerici C. Lung epithelial fluid transport and the resolution of pulmonary edema. Physiol Rev. 2002;82(3):569–600
  14. Sweezey N, Tchepichev S, Gagnon S, Fertuck K, O'Brodovich H. Female gender hormones regulate mRNA levels and function of the rat lung epithelial Na channel. Am J Physiol. 1998;274(2 Pt 1):C379–C386
  15. Verghese GM, Ware LB, Matthay BA, Matthay MA. Alveolar epithelial fluid transport and the resolution of clinically severe hydrostatic pulmonary edema. J Appl Physiol. 1999;87(4):1301–1312
  16. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med. 2000;342(18):1301–1308
  17. Calfee CS, Ware LB, Eisner MD, Parsons PE, Thompson BT, Wickersham N, et al. Plasma Receptor for Advanced Glycation End-Products And Clinical Outcomes in Acute Lung Injury. Thorax. 2008;
  18. Su X, Looney MR, Gupta N, Matthay MA. Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury. Am J Physiol Lung Cell Mol Physiol. 2009;297(1):L1–L5
  19. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med. 1992;20(6):864–874
  20. Ware LB, Fremont RD, Bastarache JA, Calfee CS, Matthay MA. Determining the etiology of pulmonary oedema by the oedema fluid-to-plasma protein ratio. Eur Respir J. 2010 Feb;35(2):331–337
  21. Murray JF, Matthay MA, Luce JM, Flick MR. An expanded definition of the adult respiratory distress syndrome. Am Rev Respir Dis. 1988;138(3):720–723
  22. Le Gall JR, Lemeshow S, Saulnier F. A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. JAMA. 1993;270(24):2957–2963
  23. Matthay MA, Flori HR, Conner ER, Ware LB. Alveolar epithelial fluid transport: basic mechanisms and clinical relevance. Proc Assoc Am Physicians. 1998;110(6):496–505
  24. Briot R, Frank JA, Uchida T, Lee JW, Calfee CS, Matthay MA. Elevated levels of the receptor for advanced glycation end products, a marker of alveolar epithelial type I cell injury, predict impaired alveolar fluid clearance in isolated perfused human lungs. Chest. 2009;135(2):269–275
  25. Yu EN, Traylor ZP, Davis IC. Effect of ventilation pressure on alveolar fluid clearance and beta-agonist responses in mice. Am J Physiol Lung Cell Mol Physiol. 2009 Oct;297(4):L785–L793

 Authors' contributions: JAB was responsible for experimental, data analysis and interpretation, and manuscript preparation, TO assisted with data analysis and manuscript preparation, MAM collected the UCSF patient samples, was responsible for the protein measurements, and assisted with data interpretation and manuscript preparation. LBW conceived the study and was responsible for collecting the Vanderbilt samples and making the protein measurements, experimental design, data interpretation, and manuscript preparation. All authors read and approved the final manuscript.

☆☆ The following were the grants received: NIH/NICHD 5 K12 HD 043483-05 and HL090785-01A1 to JAB, UCSF Pediatric Training Grant 5 T32 HD049303 to TO, NHLBI HL51856 to MAM, and NIH HL081332 and NIH HL088263 to LBW HL103836.

PII: S0883-9441(10)00168-1

doi: 10.1016/j.jcrc.2010.06.005

Journal of Critical Care
Volume 26, Issue 3 , Pages 249-256 , June 2011