Journal of Critical Care
Volume 26, Issue 3 , Pages 330.e9-330.e12 , June 2011

Protein C as an early biomarker to distinguish pneumonia from sepsis

  • Scott Gutovitz, MD

      Affiliations

    • Department of Emergency Medicine, University of Kansas Hospital, Kansas City, KS 66160
    • Corresponding Author InformationCorresponding author. Department of Emergency Medicine, 3901 Rainbow Blvd, University of Kansas Hospital, Kansas City, KS 66160, USA.
    • ,
  • Linda Papa, MD

      Affiliations

    • Department of Emergency Medicine, Orlando Health, Orlando, FL 32806
    • ,
  • Edgar Jimenez, MD

      Affiliations

    • Department of Emergency Medicine, Orlando Health, Orlando, FL 32806
    • ,
  • Jay Falk, MD

      Affiliations

    • Department of Emergency Medicine, Orlando Health, Orlando, FL 32806
    • ,
  • Leighann Wieman, MD

      Affiliations

    • Department of Emergency Medicine, Orlando Health, Orlando, FL 32806
    • ,
  • Sandra Sawyer, BA

      Affiliations

    • Department of Emergency Medicine, Orlando Health, Orlando, FL 32806
    • ,
  • Philip Giordano, MD

      Affiliations

    • Department of Emergency Medicine, Orlando Health, Orlando, FL 32806

References 

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  17. Kurosawa S, Stearns-Kurosawa DJ, Carson CW, et al. Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: lack of correlation with thrombomodulin suggests involvement of different pathological processes. Blood. 1998;91:725–727
  18. Fisher CJ, Yan SB. Protein C levels as a prognostic indicator of outcome in sepsis and related diseases. Crit Care Med. 2000;28:S49–S56
  19. Dremsizov T, Clermont G, Kellum JA, et al. Severe sepsis in community-acquired pneumonia: when does it happen, and do systemic inflammatory response syndrome criteria help predict course?. Chest. 2006;129:968–978
  20. Aujesky D, Auble TE, Yealy DM, et al. Prospective comparison of three validated prediction rules for prognosis in community-acquired pneumonia. Am J Med. 2005;118:384–392
  21. Johnstone J, Majumdar SR, Marrie TJ. The value of prognostic indices for pneumonia. Curr Infect Dis Rep. 2008;10:215–222
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☆ Conflicts of interest: None of the listed authors have any personal or financial conflicts of interest to disclose in this study.

PII: S0883-9441(10)00178-4

doi: 10.1016/j.jcrc.2010.07.002

Journal of Critical Care
Volume 26, Issue 3 , Pages 330.e9-330.e12 , June 2011

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