Elsevier

Journal of Critical Care

Volume 45, June 2018, Pages 258-262
Journal of Critical Care

Corrigendum
Corrigendum to “Effects of polymyxin B hemoperfusion on hemodynamics and prognosis in septic shock patients” [J Crit Care 43 (2018) 202–206]

https://doi.org/10.1016/j.jcrc.2017.04.046

Highlights

  • Polymyxin B hemoperfusion (PMX-HP) reduces endotoxin-induced inflammation.

  • Discrepancies in the clinical benefits of PMX-HP exist in different studies.

  • These discrepancies might result from different target population of patients.

  • PMX-HP improved survival in septic shock patients with intra-abdominal infection.

Abstract

Purpose

We designed this study to examine the clinical effects of polymyxin B hemoperfusion (PMX-HP) in septic shock patients.

Material and methods

We retrospectively examined the effects of PMX-HP in septic shock patients with intra-abdominal or gram-negative bacterial infection during October 2013–May 2016. A one-to-one matching between the PMX-HP and conventional groups was performed, and 28-day mortality, and change in inotropic score, Sequential Organ Failure Assessment (SOFA) score, and Acute Physiology and Chronic Health Evaluation II (APACHE II) score at 24 h in the two groups were compared. In addition, multivariable regression analysis and Cox proportional hazards regression model were applied in all eligible patients.

Results

Sixty-nine patients were eligible, of whom forty-eight patients were enrolled for matched cohort analysis. In matched cohort analysis, median change in inotropic score after 24 h (−23 [−33-−13] vs. −12 [−19-0], p = 0.007) differed significantly between the PMX-HP and conventional groups. Multivariable regression analysis revealed that PMX-HP was associated with lower 28-day mortality (odds ratio 0.18, 95% CI 0.04–0.92, p = 0.039) and greater improvement in inotropic and APACHE II scores.

Conclusions

PMX-HP may have potential benefits for hemodynamic and prognostic outcomes in septic shock patients with intra-abdominal or gram-negative bacterial infection.

Abbreviations

AKI
(acute kidney injury)
APACHE
(Acute Physiology and Chronic Health Evaluation)
CI
(confidence interval)
CPR
(cardiopulmonary resuscitation)
CRRT
(continuous renal replacement therapy)
GI
(gastrointestinal)
MD
(mean difference)
OR
(odds ratio)
PMX-HP
(polymyxin B hemoperfusion)
SD
(standard deviation)
SOFA
(Sequential Organ Failure Assessment)

Keywords

Abdominal infection
Endotoxin
Gram-negative bacteria
Polymyxin B hemoperfusion
Septic shock

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